Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

• Published in: PloS one Vol. 16; no. 1; p. e0245014
• Main Authors: Clabaut, Aline, Grare, Céline, Rolland-Valognes, Gaëlle, Letarouilly, Jean-Guillaume, Bourrier, Chantal, Andersen, Thomas L., Sikjær, Tanja, Rejnmark, Lars, Ejersted, Charlotte, Pastoureau, Philippe, Hardouin, Pierre, Sabatini, Massimo, Broux, Odile
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.01.2021; Public Library of Science (PLoS)
• Subjects: Adipocytes; Adipocytes - metabolism; Adipocytes - physiology; Adipose tissue; Age; Aging; Authorship; Biology and Life Sciences; Biomedical materials; Biopsy; Bone loss; Bone marrow; Cell culture; Cell Transdifferentiation - physiology; Cells, Cultured; Clean energy; Coculture Techniques; Development and progression; DNA methylation; DNA-directed RNA polymerase; Endocrinology; Experiments; Fat cells; Forensic science; Gene expression; Gene Expression Profiling; Genetic aspects; Health aspects; Human performance; Humans; Immunohistochemistry; Inflammatory diseases; Internal medicine; Life Sciences; Medicine; Medicine and Health Sciences; Osteoblasts; Osteoblasts - metabolism; Osteoblasts - physiology; Osteoporosis; Osteoporosis - genetics; Osteoporosis - metabolism; Peptidylprolyl isomerase; Physiological aspects; Polymerase chain reaction; Research and Analysis Methods; Ribonucleic acid; Risk factors; RNA; RNA polymerase; RNA polymerase II; Software; Statistical analysis; Transcriptome; Tryptophan; Tryptophan 5-monooxygenase; Tyrosine; Tyrosine 3-monooxygenase; France; Denmark; Aarhus Denmark

Our preliminary findings have lead us to propose bone marrow adipocyte secretions as new contributors to bone loss. Indeed, using a coculture model based on human bone marrow stromal cells, we previously showed that soluble factors secreted by adipocytes induced the conversion of osteoblasts towards...