Analysis of the SNARE Stx8 recycling reveals that the retromer-sorting motif has undergone evolutionary divergence

• Published in: PLoS genetics Vol. 17; no. 3; p. e1009463
• Main Authors: Yanguas, Francisco, Valdivieso, M.-Henar
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.03.2021; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Cell receptors; Divergence; Localization; Mammals; Membranes; Morphology; Natural history; Neurological diseases; Physical Sciences; Physiological aspects; Proteins; Recycling; Research and Analysis Methods; SNAP receptors; Syntaxin; Syntaxin 7; Variance analysis; Yeast; United Kingdom
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1009463

Fsv1/Stx8 is a Schizosaccharomyces pombe protein similar to mammalian syntaxin 8. stx8Δ cells are sensitive to salts, and the prevacuolar endosome (PVE) is altered in stx8Δ cells. These defects depend on the SNARE domain, data that confirm the conserved function of syntaxin8 and Stx8 in vesicle fusi...