Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

• Published in: PLoS pathogens Vol. 7; no. 7; p. e1002161
• Main Authors: Schowalter, Rachel M., Pastrana, Diana V., Buck, Christopher B.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2011; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Biosynthesis; Capsid - metabolism; Carcinoma, Merkel Cell - genetics; Carcinoma, Merkel Cell - metabolism; Carcinoma, Merkel Cell - pathology; Carcinoma, Merkel Cell - virology; CHO Cells; Chondroitin Sulfates - genetics; Chondroitin Sulfates - metabolism; Cricetinae; Cricetulus; Experiments; Genomes; Glycoproteins; Glycosaminoglycans; Health aspects; Heparitin Sulfate - genetics; Heparitin Sulfate - metabolism; Medical research; Merkel cell polyomavirus - physiology; Microbiology; Models, Biological; N-Acetylneuraminic Acid - metabolism; Physiological aspects; Polyoma virus; Propagation; Risk factors; Skin - metabolism; Skin - pathology; Skin - virology; Skin cancer; Standard deviation; Sulfates; Viral Tropism - physiology; Virus diseases; Virus Internalization; United States

Merkel cell polyomavirus (MCV or MCPyV) appears to be a causal factor in the development of Merkel cell carcinoma, a rare but highly lethal form of skin cancer. Although recent reports indicate that MCV virions are commonly shed from apparently healthy human skin, the precise cellular tropism of the...