In rice splice variants that restore the reading frame after frameshifting indel introduction are common, often induced by the indels and sometimes lead to organism-level rescue

• Published in: PLoS genetics Vol. 18; no. 2; p. e1010071
• Main Authors: Jia, Yanxiao, Qin, Chao, Traw, Milton Brian, Chen, Xiaonan, He, Ying, Kai, Jing, Yang, Sihai, Wang, Long, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.02.2022; Public Library of Science (PLoS)
• Subjects: Alternative splicing; Biology and Life Sciences; CRISPR; Engineering and Technology; Gene loci; Genetic aspects; Genetic research; Genetic variation; Genotype & phenotype; INDEL Mutation - genetics; Isoforms; Mutation; Oryza - genetics; Proteins; Reading; Reading Frames; Research and Analysis Methods; Rice; RNA splicing; China

The introduction of frameshifting non-3n indels enables the identification of gene-trait associations. However, it has been hypothesised that recovery of the original reading frame owing to usage of non-canonical splice forms could cause rescue. To date there is very little evidence for organism-lev...