Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

• Published in: PLoS genetics Vol. 15; no. 4; p. e1008043
• Main Authors: Zhao, Boxun, Wu, Qixi, Ye, Adam Yongxin, Guo, Jing, Zheng, Xianing, Yang, Xiaoxu, Yan, Linlin, Liu, Qing-Rong, Hyde, Thomas M., Wei, Liping, Huang, August Yue
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.04.2019
• Subjects: Ataxia; Base sequence; Bioinformatics; Brain; Brain research; Cerebral cortex; Deoxyribonucleic acid; DNA; Exons; Genes; Genetic aspects; Genetic variation; Genomes; Health aspects; Laboratories; Life sciences; MeCP2 protein; Methods; Methyl-CpG binding protein; Mosaicism; Mutation; Nervous system; Neurons; Proteins; Retrotransposition; Rett syndrome; Software; Tumors; Beijing China; United States > US; Maryland; China; Baltimore Maryland

Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic human-specific LINE-1 (L1Hs) inserti...