Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacy and Immune Protection

• Published in: PloS one Vol. 10; no. 6; p. e0128714
• Main Authors: Boyd, Anders, Almeida, Jorge R., Darrah, Patricia A., Sauce, Delphine, Seder, Robert A., Appay, Victor, Gorochov, Guy, Larsen, Martin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.06.2015; Public Library of Science (PLoS)
• Subjects: Algorithms; Analysis; Antigens; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - parasitology; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - parasitology; CD8-Positive T-Lymphocytes - pathology; CD8-Positive T-Lymphocytes - virology; Clone Cells; Combinatorial analysis; Control methods; Correlation analysis; Cytokines; Cytokines - biosynthesis; Cytokines - immunology; Cytotoxicity, Immunologic; Datasets; Datasets as Topic; Effectiveness; Effector cells; Evaluation; Health aspects; HIV; HIV Infections - immunology; HIV Infections - pathology; HIV Infections - virology; HIV-1 - immunology; Human health and pathology; Human immunodeficiency virus; Humans; Immunity, Innate; Immunophenotyping; Immunotherapy; In vivo methods and tests; Infection; Infections; Infectious diseases; Leishmania major - immunology; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - parasitology; Leishmaniasis, Cutaneous - pathology; Life Sciences; Lymphocytes; Lymphocytes T; Models, Immunological; Molecular chains; Parameter estimation; Pathogens; Quantitative analysis; T cells; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - parasitology; T-Lymphocyte Subsets - pathology; T-Lymphocyte Subsets - virology; France; United States > US

Understanding the factors that delineate the efficacy of T cell responses towards pathogens is crucial for our ability to develop potent therapies against infectious diseases. Multidimensional evaluation of T cell functionality at the single-cell level enables exhaustive analysis of combinatorial fu...