“Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease

• Published in: PloS one Vol. 9; no. 10; p. e111597
• Main Authors: Ilie, Marius, Hofman, Véronique, Long-Mira, Elodie, Selva, Eric, Vignaud, Jean-Michel, Padovani, Bernard, Mouroux, Jérôme, Marquette, Charles-Hugo, Hofman, Paul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Biology and Life Sciences; Blood circulation; Breast cancer; Cancer; Cancer diagnosis; Cancer metastasis; Carcinogenesis; Carcinogens; Cell migration; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Computed tomography; Diagnosis; Drug dosages; Early Detection of Cancer - methods; Female; Health aspects; Health risks; Hospitals; Human health and pathology; Humans; Immunohistochemistry; Laboratories; Life Sciences; Lung cancer; Lung diseases; Lung Neoplasms - complications; Lung Neoplasms - diagnosis; Lung Neoplasms - pathology; Lung nodules; Male; Markers; Medical diagnosis; Medical screening; Medicine; Medicine and Health Sciences; Mesenchyme; Metastasis; Middle Aged; Neoplastic Cells, Circulating - pathology; Nodules; Obstructive lung disease; Pathology; Patients; Phenotypes; Pulmonary Disease, Chronic Obstructive - complications; Pulmonology and respiratory tract; Risk factors; Senescence; Smokers; Smoking; Surgery; Systematic review; Thoracic surgery; Tissues and Organs; Tomography; Tumor cells; Tumorigenesis; Tumors; France; Senescence; Molecular Insights; Mortality; Risk; Tumorigenesis; Metastasis; Statistics; Invasion; Blood; COPD

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer. Migration of circulating tumor cells (CTCs) into the blood stream is an early event that occurs during carcinogenesis. We aimed to examine the presence of CTCs in complement to CT-scan in COPD patients without clinically...