Prolactin rs1341239 T allele may have protective role against the brick tea type skeletal fluorosis

• Published in: PloS one Vol. 12; no. 2; p. e0171011
• Main Authors: Li, Bing-Yun, Yang, Yan-Mei, Liu, Yang, Sun, Jing, Ye, Yan, Liu, Xiao-Na, Liu, Hong-Xu, Sun, Zhen-Qi, Li, Mang, Cui, Jing, Sun, Dian-Jun, Gao, Yan-Hui
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.02.2017; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alleles; Analysis; Asian Continental Ancestry Group - genetics; Autocrine signalling; Biology and Life Sciences; Bone density; Bone Diseases - chemically induced; Bone Diseases - diagnostic imaging; Bone Diseases - genetics; Bone turnover; Breastfeeding & lactation; Care and treatment; Construction materials; Cross-Sectional Studies; Cytokines; Demography; Dental caries; Disease control; Disease prevention; Drinking Water - analysis; Endocrinology; Epidemiology; Female; Females; Fluorides; Fluorides - urine; Fluorosis; Gene Frequency; Genetic polymorphisms; Health aspects; Humans; Ligands; Lymphocytes; Male; Medicine and Health Sciences; Metabolism; Middle Aged; Paracrine signalling; People and Places; Physical Sciences; Polymorphism; Polymorphism, Single Nucleotide; Prolactin; Prolactin - genetics; Risk; Risk factors; Rodents; Tea; Tea - adverse effects; Tea - chemistry; China

Prolactin (PRL) has been reported to be associated with increased bone turnover, and increased bone turnover is also a feature of skeletal fluorosis (SF). Autocrine/paracrine production of PRL is regulated by the extrapituitary promoter and a polymorphism in the extrapituitary PRL promoter at -1149...