Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates - Chen, Xinhui; Seifert, Sharon M.; Castillo-Mancilla, Jose R.; Bushman, Lane R.; Zheng, Jia-Hua; Kiser, Jennifer J.; MaWhinney, Samantha; Anderson, Peter L. (PloS one, 2016)
Keywords: Acquired immune deficiency syndrome; Adult; AIDS; Analogs; Analysis; Anti-HIV Agents - blood; Anti-HIV Agents - metabolism; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - pharmacology; Antiretroviral agents; Antiretroviral drugs; Biology and Life Sciences; Computer Simulation; Data processing; Deoxyadenine Nucleotides - metabolism; Deoxyadenosine; Deoxycytosine Nucleotides - metabolism; Diphosphates - metabolism; Disease prevention; DNA polymerases; Dosage; Drug dosages; Emtricitabine; Emtricitabine - blood; Emtricitabine - metabolism; Emtricitabine - pharmacokinetics; Emtricitabine - pharmacology; Female; Health aspects; HIV; HIV - drug effects; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Infections; Intracellular; Lentivirus; Leukocytes (mononuclear); Male; Medicine and Health Sciences; Metabolism; Metabolites; Middle Aged; Models, Biological; Nonlinear analysis; Peripheral blood mononuclear cells; Pharmaceutical sciences; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pharmacy; Plasma; Polyphosphates - metabolism; Prophylaxis; Prospective Studies; Research and Analysis Methods; Retroviridae; RNA-directed DNA polymerase; Simulation; Tenofovir; Tenofovir - blood; Tenofovir - metabolism; Tenofovir - pharmacokinetics; Tenofovir - pharmacology; Young Adult; United States--US; Colorado