Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins

• Published in: PloS one Vol. 11; no. 5; p. e0154672
• Main Authors: Chen, Wei-Ming, Sheu, Wayne H-H, Tseng, Pei-Chi, Lee, Tzong-Shyuan, Lee, Wen-Jane, Chang, Pey-Jium, Chiang, An-Na
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.05.2016; Public Library of Science (PLoS)
• Subjects: 3' Untranslated regions; ABC transporters; ABCA1 protein; Abnormalities; Analysis; Animals; Atherosclerosis; Atorvastatin; ATP; ATP Binding Cassette Transporter 1 - genetics; ATP-binding protein; Biochemistry; Biological Transport - drug effects; Biology and Life Sciences; Bone marrow; Cardiovascular disease; Cholesterol; Cholesterol - metabolism; Complications and side effects; Development and progression; Diabetes; Dosage and administration; Down-Regulation - drug effects; Down-Regulation - genetics; Drugs; Efflux; Endocrinology; Federal regulation; Female; Gastroenterology; Gene expression; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Gene regulation; Genetic aspects; Glucose; Glucose - pharmacology; Hemoglobin; Hepatology; High density lipoprotein; Homeostasis; Homeostasis - drug effects; Hospitals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Hyperglycemia; Internal medicine; Low density lipoprotein; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; Medicine; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Metabolic syndrome X; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; Middle Aged; miRNA; Modulation; Molecular biology; Physical Sciences; Physiological aspects; Post-transcription; Proteins; RAW 264.7 Cells; Ribonucleic acid; RNA; Statins; Systemic diseases; Taiwan

Metabolic syndrome (MetS) is a complicated health problem that encompasses a variety of metabolic disorders. In this study, we analyzed the relationship between the major biochemical parameters associated with MetS and circulating levels of microRNA (miR)-33, miR-103, and miR-155. We found that miRN...