Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study

• Published in: PloS one Vol. 11; no. 10; p. e0164832
• Main Authors: Liu, Kathleen D., Siew, Edward D., Reeves, W. Brian, Himmelfarb, Jonathan, Go, Alan S., Hsu, Chi-yuan, Bennett, Michael R., Devarajan, Prasad, Ikizler, T. Alp, Kaufman, James S., Kimmel, Paul L., Chinchilli, Vernon M., Parikh, Chirag R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.10.2016; Public Library of Science (PLoS)
• Subjects: Acute Kidney Injury - urine; Analysis; Biology and Life Sciences; Biomarkers; Biomarkers - urine; Blood diseases; Chronic kidney failure; Complications; Diabetes; Fatty acid-binding protein; Fatty Acid-Binding Proteins - urine; Fatty acids; Female; Gelatinase; Hepatitis A Virus Cellular Receptor 1 - analysis; Hospitalization; Humans; Hypertension; Injury analysis; Interleukin 18; Interleukin-18 - urine; Interleukins; Kidney diseases; Kidneys; Lipocalin; Lipocalin-2 - urine; Liver; Male; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Molecular chains; Nephrology; Neutrophils; Protein binding; Proteins; Renal Insufficiency, Chronic - urine; Research and Analysis Methods; Statistical analysis; Statistical methods; Time Factors; Urine; Urine - chemistry; Urine Specimen Collection - methods; Urine Specimen Collection - statistics & numerical data; Northern California; New York; San Francisco California; California; United States > US; Nashville Tennessee

Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury...