E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China

• Published in: PloS one Vol. 12; no. 1; p. e0171140
• Main Authors: Chen, Zuyi, Jing, Yaling, Wen, Qiang, Ding, Xianping, Wang, Tao, Mu, Xuemei, Chenzhang, Yuwei, Cao, Man
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.01.2017; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Bacterial proteins; Base Sequence; Binding sites; Bioinformatics; Biological evolution; Biology and Life Sciences; Cancer; Capsid Proteins - genetics; Care and treatment; Causes of; Cervical cancer; China; Clonal selection; Comparative analysis; Computer programs; Diagnosis; E7 gene; Education; Epitopes; Epitopes, B-Lymphocyte - chemistry; Epitopes, B-Lymphocyte - immunology; Evolutionary genetics; Female; Genes; Genetic aspects; Genetic polymorphisms; Genetic transformation; Genetics; Health aspects; Human papillomavirus; Humans; Immune response; Laboratories; Life sciences; Likelihood Functions; Lymphocytes B; Major histocompatibility complex; Major Histocompatibility Complex - genetics; Medicine and Health Sciences; Middle Aged; Mutation; Neural networks; Oncogene Proteins, Viral - genetics; Papillomaviridae; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus; Phylogeny; Physiological aspects; Polymorphism, Genetic; Population; Positive selection; Protein structure; Proteins; Research and Analysis Methods; Secondary structure; Selection, Genetic; Sequence Homology, Nucleic Acid; Studies; Transformation; Vaccines; Viral Envelope Proteins - genetics; Young Adult; China

Cancer of the cervix is associated with infection by certain types of human papillomavirus (HPV). The gene variants differ in immune responses and oncogenic potential. The E6 and E7 proteins encoded by high-risk HPV play a key role in cellular transformation. HPV-33 and HPV-58 types are highly preva...