Determination of rivaroxaban in patient’s plasma samples by anti-Xa chromogenic test associated to High Performance Liquid Chromatography tandem Mass Spectrometry (HPLC-MS/MS)

• Published in: PloS one Vol. 12; no. 2; p. e0171272
• Main Authors: Derogis, Priscilla Bento Matos, Sanches, Livia Rentas, de Aranda, Valdir Fernandes, Colombini, Marjorie Paris, Mangueira, Cristóvão Luis Pitangueira, Katz, Marcelo, Faulhaber, Adriana Caschera Leme, Mendes, Claudio Ernesto Albers, Ferreira, Carlos Eduardo dos Santos, França, Carolina Nunes, Guerra, João Carlos de Campos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.02.2017; Public Library of Science (PLoS)
• Subjects: Anticoagulants; Bioavailability; Biology and Life Sciences; Blood Coagulation Tests; Blood plasma; Chromatography; Chromatography, High Pressure Liquid; Drug metabolism; Drug Monitoring; Ethics; Factor Xa Inhibitors - pharmacokinetics; Factor Xa Inhibitors - therapeutic use; High performance liquid chromatography; Human subjects; Humans; Laboratories; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Medical treatment; Medicine and Health Sciences; Methods; Monitoring; Patient outcomes; Patients; Physical Sciences; Physiological aspects; Prevention; Reproducibility of Results; Research and Analysis Methods; Rivaroxaban; Rivaroxaban - pharmacokinetics; Rivaroxaban - therapeutic use; Sample preparation; Scientific imaging; Sensitivity and Specificity; Spectroscopy; Tandem Mass Spectrometry; Testing; Therapeutic drug monitoring; Thromboembolism; Thrombosis; Brazil; Canada; Mexico

Rivaroxaban is an oral direct factor Xa inhibitor, therapeutically indicated in the treatment of thromboembolic diseases. As other new oral anticoagulants, routine monitoring of rivaroxaban is not necessary, but important in some clinical circumstances. In our study a high-performance liquid chromat...