Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning
Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome...
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Published in | PloS one Vol. 11; no. 8; p. e0159707 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
01.08.2016
Public Library of Science (PLoS) |
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Abstract | Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was examined one day before gradual weaning was initiated (d -14), one day after weaning (d 1), and 8 days after weaning (d 8). On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG) identified on d 1, and 411 DEG detected eight days after weaning (P < 0.05; FDR < 0.1). No genes were differentially expressed within breed, in response to gradual weaning (P > 0.05). The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning. |
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AbstractList | Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was examined one day before gradual weaning was initiated (d -14), one day after weaning (d 1), and 8 days after weaning (d 8). On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG) identified on d 1, and 411 DEG detected eight days after weaning (P < 0.05; FDR < 0.1). No genes were differentially expressed within breed, in response to gradual weaning (P > 0.05). The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning. Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was examined one day before gradual weaning was initiated (d -14), one day after weaning (d 1), and 8 days after weaning (d 8). On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG) identified on d 1, and 411 DEG detected eight days after weaning (P < 0.05; FDR < 0.1). No genes were differentially expressed within breed, in response to gradual weaning (P > 0.05). The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning. Weaning of dairy calves is an early life husbandry management practice which involves the changeover from a liquid to a solid feed based diet. The objectives of the study were to use RNA-seq technology to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was examined one day before gradual weaning was initiated (d -14), one day after weaning (d 1), and 8 days after weaning (d 8). On d -14, 550 genes were differentially expressed between Holstein-Friesian and Jersey calves, while there were 490 differentially expressed genes (DEG) identified on d 1, and 411 DEG detected eight days after weaning (P < 0.05; FDR 0.05). The pathways, gene ontology terms, and biological functions consistently over-represented among the DEG between Holstein-Friesian and Jersey were associated with the immune response and immune cell signalling, specifically chemotaxis. Decreased transcription of several cytokines, chemokines, immunoglobulin-like genes, phagocytosis-promoting receptors and g-protein coupled receptors suggests decreased monocyte, natural killer cell, and T lymphocyte, chemotaxis and activation in Jersey compared to Holstein-Friesian calves. Knowledge of breed-specific immune responses could facilitate health management practices better tailored towards specific disease sensitivities of Holstein-Friesian and Jersey calves. Gradual weaning did not compromise the welfare of artificially-reared dairy calves, evidenced by the lack of alterations in the expression of any genes in response to gradual weaning. |
Audience | Academic |
Author | Kelly, A K McGee, M Waters, S M McCabe, M S Earley, B Johnston, D Cormican, P Kenny, D A |
AuthorAffiliation | 3 Livestock Systems Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Dunsany, Co. Meath, Ireland Institut national de la santé et de la recherche médicale - Institut Cochin, FRANCE 2 University College Dublin, School of Agriculture Food Science and Veterinary Medicine, Dublin, Belfield, Dublin, 4, Ireland 1 Animal and Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Dunsany, Co. Meath, Ireland |
AuthorAffiliation_xml | – name: 1 Animal and Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Dunsany, Co. Meath, Ireland – name: 2 University College Dublin, School of Agriculture Food Science and Veterinary Medicine, Dublin, Belfield, Dublin, 4, Ireland – name: 3 Livestock Systems Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Dunsany, Co. Meath, Ireland – name: Institut national de la santé et de la recherche médicale - Institut Cochin, FRANCE |
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Copyright | COPYRIGHT 2016 Public Library of Science 2016 Johnston et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Johnston et al 2016 Johnston et al |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: BE DAK SMW. Performed the experiments: DJ MSM. Analyzed the data: DJ PC. Contributed reagents/materials/analysis tools: BE DAK. Wrote the paper: DJ BE SMW. Read and approved the final version of the manuscript: DJ BE PC MSM SMW MM DAK AAK. Competing Interests: The authors have declared that no competing interests exist. |
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SubjectTerms | Analysis Animal husbandry Animals Beef Biology and Life Sciences Blood Calves Calves (Cattle) Cattle Cell activation Chemokines Chemokines - genetics Chemokines - metabolism Chemotaxis Cluster Analysis Cytokines Cytokines - genetics Cytokines - metabolism Disease control Down-Regulation E coli Eimeria Escherichia coli Female Food science Gene expression Genes Genomics Grasslands Health aspects Hematology Hermosilla Immune response Immune system Infections Knowledge representation Lymphatic system Lymphocytes T Medicine and Health Sciences Messenger RNA Monocytes Natural killer cells Nephelometry and Turbidimetry Neutrophils Parasitology Phagocytosis Receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Ribonucleic acid RNA RNA - chemistry RNA - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism Sequence Analysis, RNA Signal transduction Signaling Staphylococcus aureus Stress response T-Lymphocytes - immunology T-Lymphocytes - metabolism Time Factors Transcription Transcription (Genetics) Transcriptome Tuberculosis Up-Regulation Veterinary medicine Weaning |
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Title | Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning |
URI | https://www.ncbi.nlm.nih.gov/pubmed/27479136 https://www.proquest.com/docview/1808041808/abstract/ https://search.proquest.com/docview/1808605929 https://search.proquest.com/docview/1811896999 https://pubmed.ncbi.nlm.nih.gov/PMC4968839 https://doaj.org/article/2165dd4b9b7240859f6fdf9088e8c5a6 http://dx.doi.org/10.1371/journal.pone.0159707 |
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