Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes

• Published in: PloS one Vol. 11; no. 9; p. e0163318
• Main Authors: Boucher, Jonathan G., Gagné, Rémi, Rowan-Carroll, Andrea, Boudreau, Adèle, Yauk, Carole L., Atlas, Ella
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.09.2016; Public Library of Science (PLoS)
• Subjects: Adipocytes; Adipogenesis; Biology and Life Sciences; Biosynthesis; Bisphenol A; Cholestasis; Cholesterol; Comparative analysis; Computer and Information Sciences; Environmental health; Fibrosis; Functional analysis; Gene expression; Gene sequencing; Genes; Genetic aspects; Health aspects; Insulin; Laboratories; Lipid metabolism; Lipids; Liver; Liver X receptors; Medicine and Health Sciences; Metabolism; Metabolites; Obesity; Phenols; Phenols (Class of compounds); Preadipocytes; Retinoid X receptors; Ribonucleic acid; RNA; Rodents; Science; Toxicology; Transcription; Transcription (Genetics); Urine; Weight control; Canada; United States > US

Bisphenol S (BPS) is increasingly used as a replacement plasticizer for bisphenol A (BPA) but its effects on human health have not been thoroughly examined. Recent evidence indicates that both BPA and BPS induce adipogenesis, although the mechanisms leading to this effect are unclear. In an effort t...