Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1

• Published in: PloS one Vol. 12; no. 3; p. e0173454
• Main Authors: Mühle, Michael, Lehmann, Melissa, Hoffmann, Kerstin, Stern, Daniel, Kroniger, Tobias, Luttmann, Werner, Denner, Joachim
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.03.2017; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; Antigens; Antigens, Viral - genetics; Antigens, Viral - immunology; Antigens, Viral - pharmacology; Binding; Biology and Life Sciences; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cytokines; Enzyme-linked immunosorbent assay; Gene expression; Genetic aspects; Glycoprotein gp41; Health aspects; HEK293 Cells; HIV; HIV Envelope Protein gp41 - genetics; HIV Envelope Protein gp41 - immunology; HIV Envelope Protein gp41 - pharmacology; HIV-1 - genetics; HIV-1 - immunology; Homogeneity; Human immunodeficiency virus; Humans; Immune response; Immune Tolerance - drug effects; Immunoglobulins; Immunology; Immunopathogenesis; Immunosuppression; Immunosuppressive agents; Infections; Interferon-gamma; Knowledge management; Lentivirus; Leukocytes (mononuclear); Lymphocytes; Lymphocytes T; Medicine and Health Sciences; Membranes; Mice; Mice, Transgenic; Monoclonal antibodies; Monocytes; Mutation; Peptides; Peripheral blood mononuclear cells; Physiological aspects; Protein Multimerization; Proteins; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Recombinant Proteins - pharmacology; Research and Analysis Methods; Studies; Surface plasmon resonance; Trimers; Tumors; Viral envelope proteins; Viral proteins; Viruses; γ-Interferon; Germany

The transmembrane envelope (TM) protein gp41 of the human immunodeficiency virus-1 (HIV-1) plays an important role during virus infection inducing the fusion of the viral and cellular membranes. In addition, there are indications that the TM protein plays a role in the immunopathogenesis leading to...