Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury

• Published in: PloS one Vol. 11; no. 5; p. e0155504
• Main Authors: Ding, Fangrui, Li, Xuejuan, Li, Baihong, Guo, Jifan, Zhang, Yanqin, Ding, Jie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.05.2016; Public Library of Science (PLoS)
• Subjects: Alzheimer's disease; Alzheimers disease; Analysis; Animals; Biology and life sciences; Calcineurin; Calcineurin - metabolism; Calcineurin inhibitors; Calpain; Calpain - metabolism; Care and treatment; Cell Line; Complications and side effects; Cyclosporins; Cytoskeleton; Drug dosages; Drugs; Hospitals; Immunosuppressive agents; Influence; Inhibitors; Injuries; Kidneys; Medical treatment; Medicine and Health Sciences; Mice; Models, Biological; Motility; Nephrology; Nervous system; Pediatrics; Pharmacology; Phosphatase; Physiology; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; Protein expression; Proteins; Proteinuria; Puromycin; Puromycin Aminonucleoside - toxicity; Research and Analysis Methods; Rodents; siRNA; Studies; Tacrolimus

The calcineurin inhibitors cyclosporine A (CsA) and tacrolimus are widely used in the treatment of proteinuria diseases. As the direct target of these drugs, calcineurin has previously been demonstrated to play a role in proteinuria diseases. However, aside from its immune-related effects, the local...