Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans

• Published in: PloS one Vol. 11; no. 6; p. e0157195
• Main Authors: Wei, Chia-Cheng, Yen, Pei-Ling, Chang, Shang-Tzen, Cheng, Pei-Ling, Lo, Yi-Chen, Liao, Vivian Hsiu-Chuan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2016; Public Library of Science (PLoS)
• Subjects: Animals; Antioxidants; Antioxidants - pharmacology; Biology and Life Sciences; Caenorhabditis elegans; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; Camellia; Camellia - chemistry; Camellia tenuifolia; Cardiovascular disease; Cell division; Chromatography; Edible fats and oils; Edible oils; Enzymes; Fatty acids; Food science; Forkhead protein; Forkhead Transcription Factors - metabolism; Functional foods & nutraceuticals; Genetic aspects; Insulin; Insulin-like growth factors; Kinases; Mass spectrometry; Medicine and Health Sciences; Nematodes; Oil; Oils & fats; Oleic acid; Oleic Acid - pharmacology; Olive oil; Oxidation resistance; Oxidative stress; Oxidative Stress - drug effects; Physiological aspects; Plant Oils - chemistry; Plant Oils - pharmacology; Research and Analysis Methods; Scientific imaging; Seeds; Seeds - chemistry; Solvents; Tea; Transcription factors; Taiwan; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0157195

Tea seed oil is a high quality edible oil, yet lacking sufficient scientific evidences to support the nutritional and medical purposes. We identified major and minor components in Camellia tenuifolia seed oil and investigated the antioxidative activity and its underlying mechanisms in Caenorhabditis elegans. The results showed that the major constitutes in C. tenuifolia seed oil were unsaturated fatty acids (~78.4%). Moreover, two minor compounds, β-amyrin and β-sitosterol, were identified and their antioxidative activity was examined. We found that oleic acid was the major constitute in C. tenuifolia seed oil and plays a key role in the antioxidative activity of C. tenuifolia seed oil in C. elegans. This study found evidences that the transcription factor DAF-16/FOXO was involved in both oleic acid- and C. tenuifolia seed oil-mediated oxidative stress resistance in C. elegans. This study suggests the potential of C. tenuifolia seed oil as nutrient or functional foods.