Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex

• Published in: PloS one Vol. 11; no. 11; p. e0166474
• Main Authors: Lo, Yen-Lung, Liou, Gunn-Guang, Lyu, Jia-Huei, Hsiao, Michael, Hsu, Tsui-Ling, Wong, Chi-Huey
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.11.2016; Public Library of Science (PLoS)
• Subjects: Antiviral agents; Aquatic insects; Atherosclerosis; Avidity; Binding; Biology; Biology and life sciences; Biophysics; Biosensors; Blood banks; Cell Adhesion Molecules - metabolism; Cells, Cultured; Cellular signal transduction; CLEC5A protein; Cooperativity; Cytokines; DC-SIGN protein; Dengue; Dengue - metabolism; Dengue fever; Dengue virus; Dengue Virus - physiology; Ethics; Fever; Flaviviridae; Genomics; Health aspects; Humans; Infections; Interferometry; Lectins; Lectins, C-Type - metabolism; Macrophages; Macrophages - metabolism; Macrophages - virology; Mannose; Mannose-Binding Lectins - metabolism; Medicine and Health Sciences; Monosaccharides; Pandemics; Physical Sciences; Protein Binding; Receptors; Receptors, Cell Surface - metabolism; Research and Analysis Methods; Signal transduction; Signaling; Studies; Vector-borne diseases; Viral diseases; Virus diseases; Viruses

Dengue fever is a mosquito-borne viral pandemic disease that is widespread in the tropical and subtropical areas. Dengue virus uses human mannose-binding receptor (MR) and DC-SIGN on macrophages as primary receptors, and CLEC5A as signaling receptor to sense the dengue virus invasion and then to sig...