Topological Organization of Metabolic Brain Networks in Pre-Chemotherapy Cancer with Depression: A Resting-State PET Study

• Published in: PloS one Vol. 11; no. 11; p. e0166049
• Main Authors: Fang, Lei, Yao, Zhijun, An, Jianping, Chen, Xuejiao, Xie, Yuanwei, Zhao, Hui, Mao, Junfeng, Liang, Wangsheng, Ma, Xiangxing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.11.2016; Public Library of Science (PLoS)
• Subjects: Adult; Amygdala; Biology and Life Sciences; Brain; Brain - metabolism; Brain - pathology; Brain architecture; Brain Mapping; Brain research; Breast cancer; Cancer; Cancer patients; Cancer research; Chemotherapy; Clustering; Cognitive ability; Computer and Information Sciences; Correlation; Depression (Mood disorder); Depression - complications; Depression - metabolism; Depression - pathology; Depressive Disorder - complications; Depressive Disorder - metabolism; Depressive Disorder - pathology; Drug dosages; Female; Glucose - metabolism; Hospitals; Humans; Hypotheses; Information science; Male; Medical imaging; Medical research; Medicine and Health Sciences; Memory; Mental depression; Metabolic networks; Metabolic Networks and Pathways; Metabolism; Middle Aged; Neoplasms - complications; Neoplasms - metabolism; Neoplasms - pathology; Networks; Nuclear medicine; Oncology; Patients; Physiological aspects; Positron emission; Positron emission tomography; Research and Analysis Methods; Structure-function relationships; Studies; Tomography; China

This study aimed to investigate the metabolic brain network and its relationship with depression symptoms using 18F-fluorodeoxyglucose positron emission tomography data in 78 pre-chemotherapy cancer patients with depression and 80 matched healthy subjects. Functional and structural imbalance or disr...