MSX2 Induces Trophoblast Invasion in Human Placenta

• Published in: PloS one Vol. 11; no. 4; p. e0153656
• Main Authors: Liang, Hao, Zhang, Qian, Lu, Junjie, Yang, Genling, Tian, Na, Wang, Xiaojie, Tan, Yi, Tan, Dongmei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.04.2016; Public Library of Science (PLoS)
• Subjects: Abortion; Achievement tests; Analysis; Apoptosis; beta Catenin - genetics; beta Catenin - metabolism; Biology; Biology and Life Sciences; Blotting, Western; Breast cancer; Cadherins - genetics; Cadherins - metabolism; Cancer; Cell Movement; Cell Proliferation; Cells, Cultured; Chondrocytes; Chondrogenesis; Chorionic Villi - metabolism; Chorionic Villi - pathology; E-cadherin; Endocrinology; Epithelial-Mesenchymal Transition; Female; Fetuses; Gelatinase A; Gene expression; Homeobox; Homeodomain Proteins - antagonists & inhibitors; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humans; Immunoenzyme Techniques; Immunohistochemistry; Implantation; Intermediate filament proteins; Invasiveness; Kinases; Laboratory animals; Matrix metalloproteinase; Medicine and Health Sciences; Mesenchyme; Metalloproteinase; Miscarriage; Msx2 protein; Organs; Placenta; Placentation; Pre-eclampsia; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Pre-Eclampsia - pathology; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Proteins; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Small Interfering - genetics; siRNA; Teeth; Tissues; Trophoblasts - metabolism; Trophoblasts - pathology; Urine; Vimentin; β-Catenin; United States > US; China

Normal implantation depends on appropriate trophoblast growth and invasion. Inadequate trophoblast invasion results in pregnancy-related disorders, such as early miscarriage and pre-eclampsia, which are dangerous to both the mother and fetus. Msh Homeobox 2 (MSX2), a member of the MSX family of home...