Retrospective Analysis of the Survival Benefit of Induction Chemotherapy in Stage IVa-b Nasopharyngeal Carcinoma

• Published in: PloS one Vol. 11; no. 8; p. e0160758
• Main Authors: Lan, Xiao-Wen, Zou, Xue-Bin, Xiao, Yao, Tang, Jie, OuYang, Pu-Yun, Su, Zhen, Xie, Fang-Yun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.08.2016; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Analysis; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biopsy; Cancer therapies; Carcinoma - drug therapy; Carcinoma - mortality; Carcinoma - pathology; Carcinoma - radiotherapy; Care and treatment; Chemoradiotherapy; Chemotherapy; Cisplatin - administration & dosage; Clinical trials; Diagnosis; Disease control; Disease-Free Survival; Family medical history; Female; Health aspects; Humans; Induction Chemotherapy; Intensity-modulated radiotherapy; Kaplan-Meier Estimate; Laboratories; Male; Medical imaging; Medical prognosis; Medicine and Health Sciences; Metastases; Metastasis; Middle Aged; Multivariate analysis; Nasopharyngeal cancer; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; NMR; Nuclear magnetic resonance; Oncology; Organoplatinum Compounds - administration & dosage; Patient outcomes; Patients; Physical Sciences; Radiation; Radiation therapy; Radiotherapy, Intensity-Modulated; Regression analysis; Research and Analysis Methods; Retrospective Studies; Risk; Risk factors; Risk groups; Risk reduction; Survival; Test procedures; Throat cancer; Treatment Outcome; Ultrasonic imaging; China

The value of adding induction chemotherapy to chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) remains controversial, yet high-risk patients with LA-NPC have poor outcomes after chemoradiotherapy. We aimed to assess the survival benefits of induction chemotherapy in sta...