Heterosexual and Homosexual Partners Practising Unprotected Sex May Develop Allogeneic Immunity and to a Lesser Extent Tolerance

• Published in: PloS one Vol. 4; no. 11; p. e7938
• Main Authors: Kingsley, Cherry, Peters, Barry, Babaahmady, Kaboutar, Pomeroy, Laura, Rahman, Durdana, Vaughan, Robert, Lehner, Thomas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.11.2009; Public Library of Science (PLoS)
• Subjects: Adult; B cells; CD25 antigen; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Chemokines; Cohort Studies; Comparative analysis; Cytometry; Dendritic cells; Disease transmission; Epidemiology; Female; Flow cytometry; Forkhead Transcription Factors - metabolism; Foxp3 protein; Heterosexuality; HIV; HIV infections; HIV Infections - immunology; Homosexuality; Hospitals; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune System; Immune Tolerance - immunology; Immunity; Immunological tolerance; Immunology; Immunology/Immune Response; Immunology/Innate Immunity; Immunoregulation; Infections; Infectious diseases; Infectious Diseases/HIV Infection and AIDS; Infectivity; Inhibition; Interleukin-2 Receptor alpha Subunit - biosynthesis; Leukocytes, Mononuclear - cytology; Lymphocytes; Lymphocytes T; Male; Monocytes; Pathogenesis; Peripheral blood mononuclear cells; Preeclampsia; Sex; Sex industry; Sexually transmitted diseases; STD; T cell receptors; T cells; Transplants & implants; Unsafe Sex; United Kingdom > UK
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0007938

Epidemiological studies suggest that allogeneic immunity may inhibit HIV-1 transmission from mother to baby and is less frequent in multiparous than uniparous women. Alloimmune responses may also be elicited during unprotected heterosexual intercourse, which is associated ex vivo with resistance to...