Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis

• Published in: PloS one Vol. 11; no. 9; p. e0162831
• Main Authors: Kim, Do-Kyun, Beaven, Michael A, Kulinski, Joseph M, Desai, Avanti, Bandara, Geethani, Bai, Yun, Prussin, Calman, Schwartz, Lawrence B, Komarow, Hirsh, Metcalfe, Dean D, Olivera, Ana
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.09.2016; Public Library of Science (PLoS)
• Subjects: Adoptive Transfer; Adult; Allergies; Animals; Antioxidants; Antioxidants (Nutrients); Antioxidants - metabolism; Biology; Biology and Life Sciences; Blocking antibodies; Cancer; Cell Line; Damage; Development and progression; Extracellular Space - metabolism; Gene expression; Genetic aspects; Health aspects; Homeostasis; Humans; Immunology; Infectious diseases; Interleukin 6; Interleukin 6 receptors; Kinases; Laboratories; Mast cells; Mast Cells - metabolism; Mastocytoma - pathology; Mastocytosis; Mastocytosis - blood; Mastocytosis - metabolism; Medical prognosis; Medicine and Health Sciences; Mice; Middle Aged; Mutation; Mutation - genetics; Myeloproliferative diseases; Oxidation; Oxidative stress; Oxidizing agents; Oxygen; PARK7 protein; Parkinson's disease; Patients; Physical Sciences; Protein Deglycase DJ-1 - blood; Protein Deglycase DJ-1 - genetics; Protein Deglycase DJ-1 - metabolism; Protein-tyrosine kinase receptors; Proteins; Proteolysis; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Reactive oxygen species; Reactive Oxygen Species - blood; Reactive Oxygen Species - metabolism; Receptors, Interleukin-6 - metabolism; Research and Analysis Methods; Transcription; Transcription, Genetic; Tyrosine

Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant mechanisms in other myeloproliferative disorders. Ho...