Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy

• Published in: PloS one Vol. 11; no. 7; p. e0158584
• Main Authors: Sarcina, Cristina, Tinelli, Carmine, Ferrario, Francesca, Visciano, Bianca, Pani, Antonello, De Silvestri, Annalisa, De Simone, Ilaria, Del Vecchio, Lucia, Terraneo, Veronica, Furiani, Silvia, Santagostino, Gaia, Corghi, Enzo, Pozzi, Claudio
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.07.2016; Public Library of Science (PLoS)
• Subjects: Adolescent; Adrenal Cortex Hormones - pharmacology; Adrenal Cortex Hormones - therapeutic use; Adult; Aged; Azathioprine; Azathioprine - pharmacology; Azathioprine - therapeutic use; Biology and Life Sciences; Biometrics; Biopsy; Blood pressure; Clinical trials; Complications and side effects; Corticoids; Corticosteroid drugs; Corticosteroids; Creatinine; Creatinine - blood; Dosage and administration; Drug therapy; Drug Therapy, Combination; Enzymes; Epidemiology; Female; Follow-Up Studies; Glomerulonephritis, IGA - blood; Glomerulonephritis, IGA - drug therapy; Glomerulonephritis, IGA - pathology; Hemodialysis; Humans; IgA nephropathy; Immunoglobulin A; Kidney - drug effects; Kidney - pathology; Kidney diseases; Kidney failure; Kidney Function Tests; Lesions; Male; Medical prognosis; Medical research; Medical treatment; Medicine and Health Sciences; Middle Aged; Multivariate analysis; Nephrology; Patients; Physical Sciences; Proteinuria; Proteinuria - blood; Proteinuria - drug therapy; Proteinuria - pathology; Renal function; Renal insufficiency; Research and Analysis Methods; Retrospective Studies; Risk analysis; Risk factors; Steroids; Studies; Survival; Therapy; Treatment Outcome; Young Adult; Italy

The clinical course of IgA nephropathy (IgAN) and its outcome are extremely variable. Proteinuria at baseline has been considered one of the most important risk factors. More recently, mean proteinuria of follow-up (time-average proteinuria: TAp) was described as a stronger marker of renal survival,...