Simultaneous Determination of Black Tea-Derived Catechins and Theaflavins in Tissues of Tea Consuming Animals Using Ultra-Performance Liquid-Chromatography Tandem Mass Spectrometry

• Published in: PloS one Vol. 11; no. 10; p. e0163498
• Main Authors: Ganguly, Souradipta, G, Taposh Kumar, Mantha, Sudarshan, Panda, Koustubh
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.10.2016; Public Library of Science (PLoS)
• Subjects: Administration, Oral; Animal behavior; Animals; Antioxidants - chemistry; Antioxidants - therapeutic use; Biflavonoids - blood; Biflavonoids - chemistry; Biflavonoids - isolation & purification; Bioavailability; Biology and Life Sciences; Black tea; Body fluids; Catechin; Catechin - blood; Catechin - chemistry; Catechin - isolation & purification; Chromatography; Chromatography, Liquid; Computational fluid dynamics; Damage prevention; Epidemiology; Formulations; Guinea Pigs; Health aspects; Humans; In vivo methods and tests; Kidneys; Liquid chromatography; Lungs; Mass spectrometry; Mass spectroscopy; Mathematical analysis; Medicine and Health Sciences; Metabolites; Mitigation; Nutrition; Oral administration; Physical Sciences; Polyphenols; Polyphenols - blood; Polyphenols - chemistry; Polyphenols - isolation & purification; Quantitation; Research and Analysis Methods; Spectroscopy; Tandem Mass Spectrometry; Tea; Tea (Beverage); Tea - chemistry; Tea - metabolism; Theaflavins; Tissues; Urine

The bioavailability, tissue distribution and metabolic fate of the major tea polyphenols, catechins and theaflavins as well as their gallated derivatives are yet to be precisely elucidated on a single identification platform for assessment of their relative bioefficacy in vivo. This is primarily due...