Molecular Characterization and Transcriptional Regulation Analysis of the Bovine PDHB Gene

• Published in: PloS one Vol. 11; no. 7; p. e0157445
• Main Authors: Li, Anning, Zhang, Yaran, Zhao, Zhidong, Wang, Mingming, Zan, Linsen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.07.2016; Public Library of Science (PLoS)
• Subjects: 3T3-L1 Cells; 5' Flanking Region - genetics; Adipocytes; Adipose Tissue - metabolism; Animal sciences; Animals; Assaying; Base pairs; Base Sequence; Binding sites; Binding Sites - genetics; Biology and life sciences; Biotechnology; Bovidae; Cattle; Cattle - genetics; CCAAT-Enhancer-Binding Protein-beta - metabolism; CCAAT/enhancer-binding protein; Cell adhesion & migration; Cell Line; Chromatin; Clonal deletion; Cloning; Cloning, Molecular; Conserved sequence; CpG islands; CpG Islands - genetics; Dehydrogenase; Dehydrogenases; Electrophoretic mobility; Enzymes; Gene deletion; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Enzymologic; Gene regulation; Genes; Genetic aspects; Genetic regulation; Genomes; Genomics; Glycolysis; Hogs; Immunoprecipitation; Male; Metabolism; Mice; Muscles; Musculoskeletal system; Mutation; Myogenin; Myogenin - metabolism; Nucleotides; Pattern analysis; Phylogenetics; Phylogeny; Physiological aspects; Promoter Regions, Genetic - genetics; Promoters (Genetics); Protein Binding; Protein Subunits - genetics; Proteins; Pyruvate Dehydrogenase (Lipoamide) - classification; Pyruvate Dehydrogenase (Lipoamide) - genetics; Pyruvate dehydrogenase complex; Pyruvic acid; Regulations; Regulatory sequences; Research and Analysis Methods; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Sheep; Skeletal muscle; Spatial analysis; Suidae; Testis - metabolism; Transcription (Genetics); Transcription factors; Transcription initiation; Transcription Initiation Site; Tricarboxylic acid cycle; Zoology; China; United States > US

The pyruvate dehydrogenase beta subunit (PDHB) is a subunit of pyruvate dehydrogenase (E1), which catalyzes pyruvate into acetyl-CoA and provides a linkage between the tricarboxylic acid cycle (TCA) and the glycolysis pathway. Previous studies demonstrated PDHB to be positively related to the intram...