Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans

• Published in: PloS one Vol. 11; no. 7; p. e0158893
• Main Authors: Urso, Katia, Charles, Julia F., Shull, Gary E., Aliprantis, Antonios O., Balestrieri, Barbara
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.07.2016; Public Library of Science (PLoS)
• Subjects: Acidification; Animals; Anion exchanging; Bafilomycin A; Biocompatibility; Biology and Life Sciences; Biomedical materials; Candida; Candida albicans; Candida albicans - immunology; Candidiasis - genetics; Candidiasis - immunology; Cell surface; Cell walls; Chloride; Chloride-Bicarbonate Antiporters - genetics; Chloride-Bicarbonate Antiporters - immunology; Chlorides; Cytokines; Fungal infections; Fungi; Gastrointestinal tract; Gene expression; Genetic aspects; Hospitals; Immune system; Immunology; Ion exchangers; Lectins, C-Type - genetics; Lectins, C-Type - immunology; Macrophages; Macrophages, Peritoneal - immunology; Medical schools; Medicine; Medicine and Health Sciences; Mice; Mice, Knockout; Osteoclasts; Pathogens; pH effects; Phagocytes; Phagocytosis; Phagocytosis - immunology; Pharmacology; Physical Sciences; Physiological aspects; Research and Analysis Methods; Rheumatology; Rodents; Secretion; Transcription; United States; United States > US; Massachusetts

Anion exchanger 2 (Ae2; gene symbol, Slc4a2) is a plasma membrane Cl-/HCO3- exchanger expressed in the gastrointestinal tract, kidney and bone. We have previously shown that Ae2 is required for the function of osteoclasts, bone resorbing cells of the macrophage lineage, to maintain homeostatic cytop...