Biological Role of Paenilarvins, Iturin-Like Lipopeptide Secondary Metabolites Produced by the Honey Bee Pathogen Paenibacillus larvae

• Published in: PloS one Vol. 11; no. 10; p. e0164656
• Main Authors: Hertlein, Gillian, Seiffert, Marlene, Gensel, Sebastian, Garcia-Gonzalez, Eva, Ebeling, Julia, Skobalj, Ranko, Kuthning, Anja, Süssmuth, Roderich D, Genersch, Elke
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.10.2016; Public Library of Science (PLoS)
• Subjects: Air bases; American foulbrood; Analysis; Animals; Antibiotics; Antifungal agents; Apis mellifera; Apoptosis; Bacillus; Bacteria; Bees; Bees - microbiology; Bioassays; Biology and Life Sciences; Cancer; Cell Line; Cytotoxicity; Disease; Enzymes; Erythrocytes; European honeybee; Fungi; Fungicides; Genomes; Honey; Hybrids; Infections; Insect cells; Insects; Larva - microbiology; Larvae; Lipopeptides; Lipopeptides - biosynthesis; Lipopeptides - metabolism; Lipopeptides - toxicity; Medicine and Health Sciences; Metabolites; Mice; Midgut; Paenibacillus larvae; Paenibacillus larvae - metabolism; Paenibacillus larvae - physiology; Pathogenesis; Peptides; Plant metabolites; Secondary metabolites; Toxicity; Tumor cell lines; Veterinary surgeons; Virulence; Virulence factors; Germany

The Gram-positive bacterium Paenibacillus larvae (P. larvae) is the causative agent of a deadly honey bee brood disease called American Foulbrood (AFB). AFB is a notifiable epizootic in most countries and, hence, P. larvae is of considerable relevance for veterinarians and apiculturists alike. Over...