Characterization of Microbiota in Children with Chronic Functional Constipation

• Published in: PloS one Vol. 11; no. 10; p. e0164731
• Main Authors: de Meij, Tim G. J., de Groot, Evelien F. J., Eck, Anat, Budding, Andries E., Kneepkens, C. M. Frank, Benninga, Marc A., van Bodegraven, Adriaan A., Savelkoul, Paul H. M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.10.2016; Public Library of Science (PLoS)
• Subjects: Adolescent; Bacteroides fragilis; Bacteroides ovatus; Bifidobacterium longum; Biodiversity; Biology and Life Sciences; Case-Control Studies; Child; Child, Preschool; Children; Chronic Disease; Comparative analysis; Constipation; Constipation - microbiology; Constipation - physiopathology; Deoxyribonucleic acid; Disease control; Diversity indices; DNA; Etiology; Feces; Female; Gastroenterology; Gastrointestinal agents; Gastrointestinal Microbiome; Health aspects; Hepatology; Humans; Infections; Intestinal microflora; Intestine; Irritable bowel syndrome; Lactobacillus reuteri; Laxatives; Male; Mathematical analysis; Median (statistics); Medicine and Health Sciences; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Motility; Optimization; Pediatrics; People and Places; Probiotics; Regression analysis; Rodents; Species; Species diversity; Statistical analysis; Statistical methods; Subgroups; Netherlands

Disruption of the intestinal microbiota is considered an etiological factor in pediatric functional constipation. Scientifically based selection of potential beneficial probiotic strains in functional constipation therapy is not feasible due to insufficient knowledge of microbiota composition in aff...