Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis

• Published in: PloS one Vol. 6; no. 8; p. e22655
• Main Authors: Jouneau, Stéphane, Bonizec, Mélanie, Belleguic, Chantal, Desrues, Benoit, Brinchault, Graziella, Galaine, Jeanne, Gangneux, Jean-Pierre, Martin-Chouly, Corinne
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.08.2011; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents - pharmacology; Antigens; Antigens, Fungal; Antigens, Fungal - pharmacology; Aspergillus fumigatus; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - physiology; Biology; Biosynthesis; Blood; Case-Control Studies; Chemokines; Cholesterol; Cystic Fibrosis; Cystic Fibrosis - genetics; Cystic Fibrosis - metabolism; Cystic Fibrosis - microbiology; Cystic Fibrosis Transmembrane Conductance Regulator; Cystic Fibrosis Transmembrane Conductance Regulator - genetics; Cytokines; Dilution; Enzyme-linked immunosorbent assay; Fatty Acids, Monounsaturated; Fatty Acids, Monounsaturated - pharmacology; Female; Fluvastatin; Fungi; G proteins; Humans; Indoles; Indoles - pharmacology; Inflammation; Inhibitory Concentration 50; Interleukin 8; Interleukin-8 - metabolism; Intermediates; Life Sciences; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Male; Medicine; Mevalonic Acid; Mevalonic Acid - pharmacology; Microorganisms; Mutation; Nitric oxide; Patients; Phosphates; Physiological aspects; Proteins; Pseudomonas aeruginosa; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - physiology; Signal transduction; Signaling; Statins; Terpenes; Terpenes - pharmacology; Toxicology; Young Adult; France

Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we...