Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis
Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we...
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| Published in | PloS one Vol. 6; no. 8; p. e22655 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
03.08.2011
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| Abstract | Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens.
Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation.
For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. |
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| AbstractList | Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens. Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 [micro]M) and incubated for 24 h with LPS (10 [micro]g/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation. For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. BackgroundEarly in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens.ResultsWhole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation.ConclusionsFor the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens.BACKGROUNDEarly in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens.Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation.RESULTSWhole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation.For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins.CONCLUSIONSFor the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. BACKGROUND: Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens. RESULTS: Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation. CONCLUSIONS: For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens. Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation. For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. Background Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus. Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens. Results Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0-300 [micro]M) and incubated for 24 h with LPS (10 [micro]g/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation. Conclusions For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. Background Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and Aspergillus fumigatus . Since recent research has identified the anti-inflammatory properties of statins (besides their lipid-lowering effects), we investigated the effect of fluvastatin on the production of the potent neutrophil chemoattractant chemokine, IL-8, in whole blood from CF patients, stimulated by Pseudomonas aeruginosa (LPS) and Aspergillus fumigatus (AFA) antigens. Results Whole blood from adult patients with CF and from healthy volunteers was collected at the Rennes University Hospital (France). Blood was pretreated for 1 h with fluvastatin (0–300 µM) and incubated for 24 h with LPS (10 µg/mL) and/or AFA (diluted 1/200). IL-8 protein levels, quantified by ELISA, were increased in a concentration-dependent manner when cells were stimulated by LPS or AFA. Fluvastatin strongly decreased the levels of IL-8, in a concentration-dependent manner, in whole blood from CF patients. However, its inhibitory effect was decreased or absent in whole blood from healthy subjects. Furthermore, the inhibition induced by fluvastatin in CF whole blood was reversed in the presence of intermediates within the cholesterol biosynthesis pathway, mevalonate, farnesyl pyprophosphate or geranylgeranyl pyrophosphate that activate small GTPases by isoprenylation. Conclusions For the first time, the inhibitory effects of fluvastatin on CF systemic inflammation may reveal the important therapeutic potential of statins in pathological conditions associated with the over-production of pro-inflammatory cytokines and chemokines as observed during the manifestation of CF. The anti-inflammatory effect could be related to the modulation of the prenylation of signalling proteins. |
| Audience | Academic |
| Author | Galaine, Jeanne Martin-Chouly, Corinne Bonizec, Mélanie Belleguic, Chantal Brinchault, Graziella Jouneau, Stéphane Desrues, Benoit Gangneux, Jean-Pierre |
| AuthorAffiliation | 1 EA 4427 Signalisation et Réponse aux Agents Infectieux et Chimiques, Université de Rennes 1, Institut de Recherche Santé Environnement Travail, Institut Fédératif de Recherche 140, Rennes, France 2 Service de Pneumologie Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg 3 Service de Parasitologie-Mycologie, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Rennes, France |
| AuthorAffiliation_xml | – name: 2 Service de Pneumologie – name: Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg – name: 1 EA 4427 Signalisation et Réponse aux Agents Infectieux et Chimiques, Université de Rennes 1, Institut de Recherche Santé Environnement Travail, Institut Fédératif de Recherche 140, Rennes, France – name: 3 Service de Parasitologie-Mycologie, Hôpital Pontchaillou, Centre Hospitalier Universitaire de Rennes, Rennes, France |
| Author_xml | – sequence: 1 givenname: Stéphane surname: Jouneau fullname: Jouneau, Stéphane – sequence: 2 givenname: Mélanie surname: Bonizec fullname: Bonizec, Mélanie – sequence: 3 givenname: Chantal surname: Belleguic fullname: Belleguic, Chantal – sequence: 4 givenname: Benoit surname: Desrues fullname: Desrues, Benoit – sequence: 5 givenname: Graziella surname: Brinchault fullname: Brinchault, Graziella – sequence: 6 givenname: Jeanne surname: Galaine fullname: Galaine, Jeanne – sequence: 7 givenname: Jean-Pierre surname: Gangneux fullname: Gangneux, Jean-Pierre – sequence: 8 givenname: Corinne surname: Martin-Chouly fullname: Martin-Chouly, Corinne |
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| Cites_doi | 10.4049/jimmunol.170.3.1524 10.1016/S0735-1097(00)00771-3 10.1371/journal.pone.0010702 10.1177/154405910608500608 10.1016/S0887-2333(01)00028-5 10.1152/ajplung.00354.2004 10.1002/ppul.1950150506 10.1016/j.vph.2006.07.001 10.1002/ppul.1950170615 10.1164/rccm.200702-181OC 10.1097/01.CCM.0000104950.52577.97 10.1378/chest.07-0298 10.1016/j.pupt.2004.09.031 10.1007/s10238-004-0044-1 10.1056/NEJMe048326 10.1002/ppul.21230 10.1164/rccm.200501-041OC 10.1164/rccm.200901-0018OC 10.1099/jmm.0.005488-0 10.1093/jac/dkn019 10.1016/S0162-3109(00)00272-1 10.1016/j.ijcard.2006.12.024 10.1517/14728222.7.5.583 10.1016/S0192-0561(96)00068-9 10.1053/cp.1999.v66.a101210 10.1124/jpet.108.137927 10.1016/S1369-5274(99)80017-4 10.1164/ajrccm.157.6.9704086 10.1001/jama.282.24.2340 10.1164/ajrccm.161.1.9903019 10.1152/ajplung.00127.2003 10.1902/jop.2008.080051 10.1016/S0140-6736(96)05190-2 10.4049/jimmunol.172.5.2903 10.1152/ajplung.00030.2009 10.1164/rccm.200406-729OC 10.1016/S0140-6736(09)60327-5 10.1152/ajplung.00471.2005 10.1164/rccm.200810-1584OC 10.1002/jlb.55.6.749 10.1016/j.athoracsur.2006.10.065 10.1128/CMR.4.1.35 10.1097/00029330-200809010-00018 10.1385/CRIAI:23:1:041 10.1016/0021-9150(93)90107-6 10.1182/blood.V88.12.4611.bloodjournal88124611 10.1164/rccm.200205-410OC 10.1016/S0021-9150(98)00074-4 10.1046/j.1469-1809.2003.00028.x 10.1124/jpet.110.171462 10.1016/j.jpeds.2007.04.009 10.1111/j.1440-1681.2006.04440.x |
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| Copyright | COPYRIGHT 2011 Public Library of Science 2011 Jouneau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License Jouneau et al. 2011 |
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| DOI | 10.1371/journal.pone.0022655 |
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| DocumentTitleAlternate | Statin Anti-Inflammatory Effect in Cystic Fibrosis |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SJ J-PG CM-C. Performed the experiments: SJ MB JG CM-C. Analyzed the data: SJ J-PG CM-C. Contributed reagents/materials/analysis tools: SJ CB BD GB J-PG CM-C. Wrote the paper: SJ J-PG CM-C. |
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| References | HW Yao (ref16) 2006; 33 A Augarten (ref26) 2004; 4 JS Elborn (ref29) 1994; 17 K Takano (ref35) 2010; 336 BP O'Sullivan (ref53) 2009; 373 ME Falagas (ref34) 2008; 61 MW Konstan (ref3) 2007; 176 A Bjerre (ref18) 2004; 32 L Björkhem-Bergman (ref11) 2010; 5 G Kronborg (ref28) 1993; 15 NE Kreiselmeier (ref51) 2003; 285 MW Lindhom (ref8) 2007; 46 AP Bellanger (ref22) 2009; 58 XM Ou (ref43) 2008; 121 MP Horn (ref40) 2008; 326 T Hartung (ref17) 1999; 66 I Langezaal (ref31) 2001; 15 PH Gilligan (ref20) 1991; 4 PA Kiener (ref46) 2001; 1 LS Nixon (ref32) 1998; 157 A Corsini (ref47) 1993; 101 CJ Vaughan (ref5) 1996; 348 G Földes (ref49) 2008; 124 AM van Heeckeren (ref1) 2000; 161 D Zhao (ref50) 2003; 7 A McKay (ref7) 2004; 172 R Terkeltaub (ref39) 1994; 55 M Ouagued (ref19) 2005; 18 D Ferro (ref10) 2000; 36 SD Sagel (ref30) 2002; 23 NC Sturges (ref25) 2010; 45 C Svanborg (ref23) 1999; 2 BA Johnson (ref45) 2003; 167 BP Leung (ref6) 2003; 170 JH Lee (ref13) 2005; 172 MR Ehrenstein (ref9) 2005; 352 S Niwa (ref38) 1996; 18 JI Keddissi (ref12) 2007; 132 JC LaRosa (ref33) 1999; 282 N De Bont (ref36) 1998; 139 RK Rowntree (ref52) 2003; 67 K Sakoda (ref44) 2006; 85 M Shyamsundar (ref48) 2009; 179 AA Zeki (ref14) 2009; 180 J Cazalis (ref21) 2008; 79 M Chello (ref41) 2007; 83 S Schmitt-Grohé (ref27) 2005; 29 LC Lands (ref4) 2007; 151 F Goldman (ref37) 1996; 88 JR Jacobson (ref15) 2005; 288 I Kuwahara (ref24) 2006; 291 MB Fessler (ref42) 2005; 171 RW Vandivier (ref2) 2009; 297 10612322 - JAMA. 1999 Dec 22-29;282(24):2340-6 19024099 - Chin Med J (Engl). 2008 Sep 5;121(17):1680-7 9699902 - Atherosclerosis. 1998 Jul;139(1):147-52 16723648 - J Dent Res. 2006 Jun;85(6):520-3 17383753 - Int J Cardiol. 2008 Feb 20;124(1):80-5 14978092 - J Immunol. 2004 Mar 1;172(5):2903-8 17908708 - Chest. 2007 Dec;132(6):1764-71 18771379 - J Periodontol. 2008 Sep;79(9):1762-8 12940920 - Ann Hum Genet. 2003 Sep;67(Pt 5):471-85 18263570 - J Antimicrob Chemother. 2008 Apr;61(4):774-85 15591471 - Am J Respir Crit Care Med. 2005 Mar 15;171(6):606-15 8977253 - Blood. 1996 Dec 15;88(12):4611-9 12162105 - Clin Rev Allergy Immunol. 2002 Aug;23(1):41-57 16942919 - Vascul Pharmacol. 2007 Feb;46(2):91-6 19633071 - Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L677-86 9089010 - Int J Immunopharmacol. 1996 Nov;18(11):669-75 11367508 - Int Immunopharmacol. 2001 Jan;1(1):105-18 19324974 - Am J Respir Crit Care Med. 2009 Jun 15;179(12):1107-14 15579374 - Cytokine. 2005 Jan 7;29(1):18-23 10047563 - Curr Opin Microbiol. 1999 Feb;2(1):99-105 9620903 - Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1764-9 10546926 - Clin Pharmacol Ther. 1999 Oct;66(4):415-24 8195701 - J Leukoc Biol. 1994 Jun;55(6):749-55 17719932 - J Pediatr. 2007 Sep;151(3):249-54 15635116 - N Engl J Med. 2005 Jan 6;352(1):73-5 12948935 - Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1286-95 14758160 - Crit Care Med. 2004 Feb;32(2):433-8 10619831 - Am J Respir Crit Care Med. 2000 Jan;161(1):271-9 19608720 - Am J Respir Crit Care Med. 2009 Oct 15;180(8):731-40 19141733 - J Med Microbiol. 2009 Feb;58(Pt 2):174-9 19403164 - Lancet. 2009 May 30;373(9678):1891-904 1900735 - Clin Microbiol Rev. 1991 Jan;4(1):35-51 10933353 - J Am Coll Cardiol. 2000 Aug;36(2):427-31 16922808 - Clin Exp Pharmacol Physiol. 2006 Sep;33(9):793-7 21057058 - J Pharmacol Exp Ther. 2011 Feb;336(2):381-90 7993482 - Pediatr Pulmonol. 1994 Jun;17(6):411-2 16632517 - Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L407-16 16002570 - Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93 12538717 - J Immunol. 2003 Feb 1;170(3):1524-30 12615629 - Am J Respir Crit Care Med. 2003 May 1;167(9):1271-8 14498821 - Expert Opin Ther Targets. 2003 Oct;7(5):583-92 17383342 - Ann Thorac Surg. 2007 Apr;83(4):1374-80 15665042 - Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1026-32 8216498 - Atherosclerosis. 1993 Jun;101(1):117-25 8874463 - Lancet. 1996 Oct 19;348(9034):1079-82 18388257 - J Pharmacol Exp Ther. 2008 Jul;326(1):135-43 15607127 - Pulm Pharmacol Ther. 2005;18(1):49-54 8327288 - Pediatr Pulmonol. 1993 May;15(5):292-7 17872492 - Am J Respir Crit Care Med. 2007 Dec 1;176(11):1084-9 20502712 - PLoS One. 2010;5(5):e10702 20717938 - Pediatr Pulmonol. 2010 Sep;45(9):883-9 11566555 - Toxicol In Vitro. 2001 Aug-Oct;15(4-5):313-8 15672947 - Clin Exp Med. 2004 Oct;4(2):99-102 |
| References_xml | – volume: 170 start-page: 1524 year: 2003 ident: ref6 article-title: A novel anti-inflammatory role for simvastatin in inflammatory arthritis. publication-title: J Immunol doi: 10.4049/jimmunol.170.3.1524 – volume: 36 start-page: 427 year: 2000 ident: ref10 article-title: Simvastatin inhibits the monocyte expression of pro-inflammatory cytokines in patients with hypercholesterolemia. publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(00)00771-3 – volume: 5 start-page: e10702 year: 2010 ident: ref11 article-title: Statin treatment and mortality in bacterial infections–a systematic review and meta-analysis. publication-title: PLoS One doi: 10.1371/journal.pone.0010702 – volume: 85 start-page: 520 year: 2006 ident: ref44 article-title: Simvastatin decreases IL-6 and IL-8 production in epithelial cells. publication-title: J Dent Res doi: 10.1177/154405910608500608 – volume: 15 start-page: 313 year: 2001 ident: ref31 article-title: Whole blood cytokine response as a measure of immunotoxicity. publication-title: Toxicol In Vitro doi: 10.1016/S0887-2333(01)00028-5 – volume: 288 start-page: L1026 year: 2005 ident: ref15 article-title: Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00354.2004 – volume: 29 start-page: 18 year: 2005 ident: ref27 article-title: Interleukin-8 in whole blood and clinical status in cystic fibrosis. publication-title: Cytokine – volume: 15 start-page: 292 year: 1993 ident: ref28 article-title: Cytokines in sputum and serum from patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection as markers of destructive inflammation in the lungs. publication-title: Pediatr Pulmonol doi: 10.1002/ppul.1950150506 – volume: 46 start-page: 91 year: 2007 ident: ref8 article-title: Simvastatin stimulates interleukine-1β secretion through an isoprenylation-dependent mechanism. publication-title: Vasc Pharmacol doi: 10.1016/j.vph.2006.07.001 – volume: 17 start-page: 411 year: 1994 ident: ref29 article-title: On tumor necrosis factor α in CF. publication-title: Pediatr Pulmonol doi: 10.1002/ppul.1950170615 – volume: 176 start-page: 1084 year: 2007 ident: ref3 article-title: Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200702-181OC – volume: 32 start-page: 433 year: 2004 ident: ref18 article-title: Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock. publication-title: Crit Care Med doi: 10.1097/01.CCM.0000104950.52577.97 – volume: 132 start-page: 1764 year: 2007 ident: ref12 article-title: The use of statins and lung function in current and former smokers. publication-title: Chest doi: 10.1378/chest.07-0298 – volume: 18 start-page: 49 year: 2005 ident: ref19 article-title: The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients. publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2004.09.031 – volume: 4 start-page: 99 year: 2004 ident: ref26 article-title: Systemic inflammatory mediators and cystic fibrosis genotype. publication-title: Clin Exp Med doi: 10.1007/s10238-004-0044-1 – volume: 352 start-page: 73 year: 2005 ident: ref9 article-title: Statins for atherosclerosis – as good as it gets? publication-title: N Engl J Med doi: 10.1056/NEJMe048326 – volume: 45 start-page: 883 year: 2010 ident: ref25 article-title: Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4. publication-title: Pediatr Pulm doi: 10.1002/ppul.21230 – volume: 172 start-page: 987 year: 2005 ident: ref13 article-title: Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200501-041OC – volume: 180 start-page: 731 year: 2009 ident: ref14 article-title: Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200901-0018OC – volume: 58 start-page: 174 year: 2009 ident: ref22 article-title: Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549. publication-title: J Med Microbiol doi: 10.1099/jmm.0.005488-0 – volume: 61 start-page: 774 year: 2008 ident: ref34 article-title: Statins for infection and sepsis: a systematic review of the clinical evidence. publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkn019 – volume: 1 start-page: 105 year: 2001 ident: ref46 article-title: Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors. publication-title: Int Immunopharmacol doi: 10.1016/S0162-3109(00)00272-1 – volume: 124 start-page: 80 year: 2008 ident: ref49 article-title: Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure. publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2006.12.024 – volume: 7 start-page: 583 year: 2003 ident: ref50 article-title: Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. publication-title: Expert Opin Ther Targets doi: 10.1517/14728222.7.5.583 – volume: 18 start-page: 669 year: 1996 ident: ref38 article-title: Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line. publication-title: Int J Immunopharmacol doi: 10.1016/S0192-0561(96)00068-9 – volume: 66 start-page: 415 year: 1999 ident: ref17 article-title: Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions. publication-title: Clin Pharmacol Ther doi: 10.1053/cp.1999.v66.a101210 – volume: 326 start-page: 135 year: 2008 ident: ref40 article-title: Simvastatin inhibits Staphylococcus aureus host cell invasion through modulation of isoprenoid intermediates. publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.108.137927 – volume: 2 start-page: 99 year: 1999 ident: ref23 article-title: Cytokine responses during mucosal infections: role in disease pathogenesis and host defence. publication-title: Curr Opin Microbiol doi: 10.1016/S1369-5274(99)80017-4 – volume: 157 start-page: 1764 year: 1998 ident: ref32 article-title: Circulating immunoreactive interleukin-6 in cystic fibrosis. publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.6.9704086 – volume: 282 start-page: 2340 year: 1999 ident: ref33 article-title: Effect of statins on risk of coronary disease. A meta-analysis of randomized controlled trials. publication-title: JAMA doi: 10.1001/jama.282.24.2340 – volume: 161 start-page: 271 year: 2000 ident: ref1 article-title: Effect of Pseudomonas infection on weight loss, lung mechanics, and cytokines in mice. publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.1.9903019 – volume: 285 start-page: L1286 year: 2003 ident: ref51 article-title: Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells. publication-title: AJP - Lung Physiol doi: 10.1152/ajplung.00127.2003 – volume: 79 start-page: 1762 year: 2008 ident: ref21 article-title: Doxycycline reduces lipopolysaccharide-induced inflammatory mediator secretion in macrophage and ex vivo human whole blood models. publication-title: J Periodontol doi: 10.1902/jop.2008.080051 – volume: 348 start-page: 1079 year: 1996 ident: ref5 article-title: Statins do more than just lower cholesterol. publication-title: Lancet doi: 10.1016/S0140-6736(96)05190-2 – volume: 172 start-page: 2903 year: 2004 ident: ref7 article-title: A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. publication-title: J Immunol doi: 10.4049/jimmunol.172.5.2903 – volume: 297 start-page: L677 year: 2009 ident: ref2 article-title: Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00030.2009 – volume: 171 start-page: 606 year: 2005 ident: ref42 article-title: A role for hydroxy-methylglutaryl coenzyme A reductase in pulmonary inflammation and host defense. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200406-729OC – volume: 373 start-page: 1891 year: 2009 ident: ref53 article-title: Cystic fibrosis. publication-title: Lancet doi: 10.1016/S0140-6736(09)60327-5 – volume: 291 start-page: L407 year: 2006 ident: ref24 article-title: Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-κB activation via EGFR transactivation in a lung epithelial cell line. publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00471.2005 – volume: 179 start-page: 1107 year: 2009 ident: ref48 article-title: Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200810-1584OC – volume: 55 start-page: 749 year: 1994 ident: ref39 article-title: Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells. publication-title: J Leukocyte Biol doi: 10.1002/jlb.55.6.749 – volume: 83 start-page: 1374 year: 2007 ident: ref41 article-title: Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction after coronary surgery. publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2006.10.065 – volume: 4 start-page: 35 year: 1991 ident: ref20 article-title: Microbiology of airway disease in patients with cystic fibrosis. publication-title: Clin Microbiol Rev doi: 10.1128/CMR.4.1.35 – volume: 121 start-page: 1680 year: 2008 ident: ref43 article-title: Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats. publication-title: Chin Med J doi: 10.1097/00029330-200809010-00018 – volume: 23 start-page: 41 year: 2002 ident: ref30 article-title: Monitoring inflammation in CF. publication-title: Clin Rev Allerg Immunol doi: 10.1385/CRIAI:23:1:041 – volume: 101 start-page: 117 year: 1993 ident: ref47 article-title: Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG CoA reductase. publication-title: Atherosclerosis doi: 10.1016/0021-9150(93)90107-6 – volume: 88 start-page: 4611 year: 1996 ident: ref37 article-title: Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras. publication-title: Blood doi: 10.1182/blood.V88.12.4611.bloodjournal88124611 – volume: 167 start-page: 1271 year: 2003 ident: ref45 article-title: Statin use is associated with improved function and survival of lung allografts. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200205-410OC – volume: 139 start-page: 147 year: 1998 ident: ref36 article-title: LPS-induced cytokine production and expression of LPS-receptors by peripheral blood mononuclear cells of patients with familial hypercholesterolemia and the effect of HMG-CoA reductase inhibitors. publication-title: Atherosclerosis doi: 10.1016/S0021-9150(98)00074-4 – volume: 67 start-page: 471 year: 2003 ident: ref52 article-title: The phenotypic consequences of CFTR mutations. publication-title: Ann Hum Genet doi: 10.1046/j.1469-1809.2003.00028.x – volume: 336 start-page: 381 year: 2010 ident: ref35 article-title: Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages. publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.110.171462 – volume: 151 start-page: 249 year: 2007 ident: ref4 article-title: High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial. publication-title: J Pediatr doi: 10.1016/j.jpeds.2007.04.009 – volume: 33 start-page: 793 year: 2006 ident: ref16 article-title: Protective effects of pravastatin in murine lipopolysaccharide-induced acute lung injury. publication-title: Clin Exp Pharmacol Physiol doi: 10.1111/j.1440-1681.2006.04440.x – reference: 15591471 - Am J Respir Crit Care Med. 2005 Mar 15;171(6):606-15 – reference: 12940920 - Ann Hum Genet. 2003 Sep;67(Pt 5):471-85 – reference: 12162105 - Clin Rev Allergy Immunol. 2002 Aug;23(1):41-57 – reference: 19633071 - Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L677-86 – reference: 8195701 - J Leukoc Biol. 1994 Jun;55(6):749-55 – reference: 11566555 - Toxicol In Vitro. 2001 Aug-Oct;15(4-5):313-8 – reference: 9699902 - Atherosclerosis. 1998 Jul;139(1):147-52 – reference: 15635116 - N Engl J Med. 2005 Jan 6;352(1):73-5 – reference: 14758160 - Crit Care Med. 2004 Feb;32(2):433-8 – reference: 16922808 - Clin Exp Pharmacol Physiol. 2006 Sep;33(9):793-7 – reference: 14978092 - J Immunol. 2004 Mar 1;172(5):2903-8 – reference: 19024099 - Chin Med J (Engl). 2008 Sep 5;121(17):1680-7 – reference: 16942919 - Vascul Pharmacol. 2007 Feb;46(2):91-6 – reference: 17383342 - Ann Thorac Surg. 2007 Apr;83(4):1374-80 – reference: 8216498 - Atherosclerosis. 1993 Jun;101(1):117-25 – reference: 18388257 - J Pharmacol Exp Ther. 2008 Jul;326(1):135-43 – reference: 17719932 - J Pediatr. 2007 Sep;151(3):249-54 – reference: 9089010 - Int J Immunopharmacol. 1996 Nov;18(11):669-75 – reference: 15579374 - Cytokine. 2005 Jan 7;29(1):18-23 – reference: 20717938 - Pediatr Pulmonol. 2010 Sep;45(9):883-9 – reference: 10546926 - Clin Pharmacol Ther. 1999 Oct;66(4):415-24 – reference: 19608720 - Am J Respir Crit Care Med. 2009 Oct 15;180(8):731-40 – reference: 8327288 - Pediatr Pulmonol. 1993 May;15(5):292-7 – reference: 9620903 - Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1764-9 – reference: 18263570 - J Antimicrob Chemother. 2008 Apr;61(4):774-85 – reference: 16632517 - Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L407-16 – reference: 21057058 - J Pharmacol Exp Ther. 2011 Feb;336(2):381-90 – reference: 20502712 - PLoS One. 2010;5(5):e10702 – reference: 18771379 - J Periodontol. 2008 Sep;79(9):1762-8 – reference: 12538717 - J Immunol. 2003 Feb 1;170(3):1524-30 – reference: 16002570 - Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93 – reference: 14498821 - Expert Opin Ther Targets. 2003 Oct;7(5):583-92 – reference: 7993482 - Pediatr Pulmonol. 1994 Jun;17(6):411-2 – reference: 19403164 - Lancet. 2009 May 30;373(9678):1891-904 – reference: 19324974 - Am J Respir Crit Care Med. 2009 Jun 15;179(12):1107-14 – reference: 8874463 - Lancet. 1996 Oct 19;348(9034):1079-82 – reference: 15607127 - Pulm Pharmacol Ther. 2005;18(1):49-54 – reference: 11367508 - Int Immunopharmacol. 2001 Jan;1(1):105-18 – reference: 15665042 - Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1026-32 – reference: 1900735 - Clin Microbiol Rev. 1991 Jan;4(1):35-51 – reference: 16723648 - J Dent Res. 2006 Jun;85(6):520-3 – reference: 17872492 - Am J Respir Crit Care Med. 2007 Dec 1;176(11):1084-9 – reference: 10619831 - Am J Respir Crit Care Med. 2000 Jan;161(1):271-9 – reference: 19141733 - J Med Microbiol. 2009 Feb;58(Pt 2):174-9 – reference: 10612322 - JAMA. 1999 Dec 22-29;282(24):2340-6 – reference: 8977253 - Blood. 1996 Dec 15;88(12):4611-9 – reference: 17908708 - Chest. 2007 Dec;132(6):1764-71 – reference: 12948935 - Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1286-95 – reference: 10933353 - J Am Coll Cardiol. 2000 Aug;36(2):427-31 – reference: 17383753 - Int J Cardiol. 2008 Feb 20;124(1):80-5 – reference: 10047563 - Curr Opin Microbiol. 1999 Feb;2(1):99-105 – reference: 15672947 - Clin Exp Med. 2004 Oct;4(2):99-102 – reference: 12615629 - Am J Respir Crit Care Med. 2003 May 1;167(9):1271-8 |
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| Snippet | Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa and... Background Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa... BACKGROUND: Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas... BackgroundEarly in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa... Background Early in life, patients with cystic fibrosis (CF) are infected with microorganisms including bacteria and fungi, particularly Pseudomonas aeruginosa... |
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| SubjectTerms | Adolescent Adult Anti-Inflammatory Agents Anti-Inflammatory Agents - pharmacology Antigens Antigens, Fungal Antigens, Fungal - pharmacology Aspergillus fumigatus Aspergillus fumigatus - metabolism Aspergillus fumigatus - physiology Biology Biosynthesis Blood Case-Control Studies Chemokines Cholesterol Cystic Fibrosis Cystic Fibrosis - genetics Cystic Fibrosis - metabolism Cystic Fibrosis - microbiology Cystic Fibrosis Transmembrane Conductance Regulator Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cytokines Dilution Enzyme-linked immunosorbent assay Fatty Acids, Monounsaturated Fatty Acids, Monounsaturated - pharmacology Female Fluvastatin Fungi G proteins Humans Indoles Indoles - pharmacology Inflammation Inhibitory Concentration 50 Interleukin 8 Interleukin-8 - metabolism Intermediates Life Sciences Lipopolysaccharides Lipopolysaccharides - pharmacology Male Medicine Mevalonic Acid Mevalonic Acid - pharmacology Microorganisms Mutation Nitric oxide Patients Phosphates Physiological aspects Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - physiology Signal transduction Signaling Statins Terpenes Terpenes - pharmacology Toxicology Young Adult |
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| Title | Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/21826199 https://www.proquest.com/docview/1306895288 https://www.proquest.com/docview/882086455 https://hal.science/hal-00680962 https://pubmed.ncbi.nlm.nih.gov/PMC3149602 https://doaj.org/article/af5ebd1de21542aaa2ab4f56224d757a http://dx.doi.org/10.1371/journal.pone.0022655 |
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