Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections

• Published in: PloS one Vol. 11; no. 6; p. e0158683
• Main Authors: Mackie, Joanna, Szabo, Edina K, Urgast, Dagmar S, Ballou, Elizabeth R, Childers, Delma S, MacCallum, Donna M, Feldmann, Joerg, Brown, Alistair J P
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.06.2016; Public Library of Science (PLoS)
• Subjects: Ablation; Animals; Biology and Life Sciences; Candida albicans; Candida albicans - genetics; Candidiasis - microbiology; Carbon; Copper; Copper - metabolism; Copper - poisoning; Disease Models, Animal; Disease Progression; Efflux; Fungal Proteins - genetics; Fungi; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Fungal; Gene mapping; Homeostasis; Immunity; Immunohistochemistry; Infections; Kidney - metabolism; Kidney diseases; Kidneys; Laboratories; Laser ablation; Liver - metabolism; Mass Spectrometry; Mass spectroscopy; Medicine; Medicine and Health Sciences; Metabolism; Mice; Micronutrients; Nutrition; Oxidation resistance; Oxidative Stress; Physical Sciences; Poisoning; Profiling; Research and Analysis Methods; Science; Spleen; Spleen - metabolism; Trace elements; Virulence; Yeast; United Kingdom > UK

Nutritional immunity is a process whereby an infected host manipulates essential micronutrients to defend against an invading pathogen. We reveal a dynamic aspect of nutritional immunity during infection that involves copper assimilation. Using a combination of laser ablation inductively coupled mas...