Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis

• Published in: PloS one Vol. 11; no. 6; p. e0157105
• Main Authors: Kan, Shun-Li, Li, Yan, Ning, Guang-Zhi, Yuan, Zhi-Fang, Chen, Ling-Xiao, Bi, Ming-Chao, Sun, Jing-Cheng, Feng, Shi-Qing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.06.2016; Public Library of Science (PLoS)
• Subjects: Analgesics; Analysis; Antibodies, Monoclonal, Humanized - therapeutic use; Arthritis; Biocompatibility; Biology and Life Sciences; Care and treatment; Clinical trials; Complications and side effects; Confidence intervals; Critical care; Dose-Response Relationship, Drug; Drugs; Growth factors; Health aspects; Hospitals; Humans; Intervention; Knee; Medicine and Health Sciences; Meta-analysis; Nonsteroidal anti-inflammatory agents; Older people; Osteoarthritis; Osteoarthritis, Knee - drug therapy; Osteoarthritis, Knee - epidemiology; Pain; Pain Measurement; Patients; Peripheral neuropathy; Physical Sciences; Quality of life; Randomization; Research and Analysis Methods; Rheumatic diseases; Rheumatism; Safety; Severity of Illness Index; Studies; Surgeons; Systematic review; Treatment Outcome; Ontario; China

Tanezumab is a new therapeutic intervention for patients with osteoarthritis (OA) of the knee. We performed the present meta-analysis to appraise the efficacy and safety of tanezumab for patients with knee OA. We systematically searched randomized controlled trials from PubMed, EMBASE, and the Cochr...