Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

• Published in: PloS one Vol. 11; no. 10; p. e0164763
• Main Authors: Si, Yanna, Zhang, Yuan, Han, Liu, Chen, Lihai, Xu, Yajie, Sun, Fan, Ji, Muhuo, Yang, Jianjun, Bao, Hongguang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.10.2016; Public Library of Science (PLoS)
• Subjects: Adrenergic receptors; Anesthesia; Anesthesiology; Animals; Apoptosis; Attenuation; Bcl-2 protein; Biology and Life Sciences; Brain-derived neurotrophic factor; Caspase; Caspase-3; Cognition; Cognition Disorders - prevention & control; Cognitive ability; Cytokines; Dexmedetomidine - pharmacology; Experiments; Exposure; Halides; Hospitals; House mouse; Inhibitors; Ischemia; Isoflurane; Isoflurane - pharmacology; Janus kinase 2; Janus Kinase 2 - metabolism; Laboratory animals; Medical research; Medicine and Health Sciences; Memory; Mice; Phosphorylation; Pretreatment of water; Proteins; Rodents; Signal transduction; Signaling; Spatial discrimination learning; Spatial memory; Stat3 protein; STAT3 Transcription Factor - metabolism; Traumatic brain injury; United States > US; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0164763

Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether dexmedetomidine could also alleviate isoflurane-induced cognitive deficits in senile animals. Senile male C57BL/6 mice (20 mont...