Interleukin-7, a new cytokine targeting the mouse hypothalamic arcuate nucleus: role in body weight and food intake regulation

• Published in: PloS one Vol. 5; no. 4; p. e9953
• Main Authors: Macia, Laurence, Viltart, Odile, Delacre, Myriam, Sachot, Christelle, Héliot, Laurent, Di Santo, James P, Wolowczuk, Isabelle
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2010; Public Library of Science (PLoS)
• Series: PLoS ONE
• Subjects: Adipose tissue; Animals; Appetite Regulation - drug effects; Arcuate nucleus; Body weight; Body Weight - drug effects; Brain; Brain Chemistry - drug effects; Brain research; c-Fos protein; Cell death; Cognitive science; Cytokines; Diabetes and Endocrinology/Endocrinology; Diabetes and Endocrinology/Neuroendocrinology and Pituitary; Diabetes and Endocrinology/Obesity; Evaluation; Feeding behavior; Food; Food intake; Fos protein; Gene expression; Glutamate; Histology; Homeostasis; Hypothalamus; Hypothalamus - cytology; Hypothalamus - drug effects; Hypothalamus - physiology; Immunomodulation; Injection; Insulin resistance; Interleukin 7; Interleukin-7 - administration & dosage; Interleukin-7 - pharmacology; Interleukins; Kinases; Laboratories; Lymphocytes; Lymphopoiesis; Melanocyte stimulating hormone; Metabolism; Mice; Monosodium glutamate; Nervous system; Neurons - chemistry; Neurons - drug effects; Neuropeptides; Neurosciences; Nuclei (cytology); Obesity; Obesity - chemically induced; Obesity - prevention & control; Phosphorylation; Phosphorylation - drug effects; Physiology; Proopiomelanocortin; Proteins; Receptors, Interleukin-7 - analysis; Rodents; Skin; Skin diseases; Stat3 protein; STAT3 Transcription Factor - metabolism; Tumor necrosis factor-TNF; Weight control; France; Obesity; Phosphorylation; Receptors; Animals; Appetite Regulation; Body Weight; Neurons; Brain Chemistry; Mice; STAT3 Transcription Factor; Hypothalamus; Interleukin-7

Body weight is controlled through peripheral (white adipose tissue) and central (mainly hypothalamus) mechanisms. We have recently obtained evidence that overexpression of interleukin (IL)-7, a critical cytokine involved in lymphopoiesis, can protect against the development of diet-induced obesity i...