Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization
Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent. In this study, we employed an immunoproteomic approach and identified ba...
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Published in | PloS one Vol. 5; no. 12; p. e14361 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
17.12.2010
Public Library of Science (PLoS) |
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Abstract | Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent. In this study, we employed an immunoproteomic approach and identified bacterial Elongation factor-Tu (EF-Tu) as a potential vaccine antigen. EF-Tu is membrane-associated, secreted in outer membrane vesicles (OMVs), and immunogenic during Burkholderia infection in the murine model of melioidosis. Active immunization with EF-Tu induced antigen-specific antibody and cell-mediated immune responses in mice. Mucosal immunization with EF-Tu also reduced lung bacterial loads in mice challenged with aerosolized B. thailandensis. Our data support the utility of EF-Tu as a novel vaccine immunogen against bacterial infection. |
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AbstractList | Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent. In this study, we employed an immunoproteomic approach and identified bacterial Elongation factor-Tu (EF-Tu) as a potential vaccine antigen. EF-Tu is membrane-associated, secreted in outer membrane vesicles (OMVs), and immunogenic during Burkholderia infection in the murine model of melioidosis. Active immunization with EF-Tu induced antigen-specific antibody and cell-mediated immune responses in mice. Mucosal immunization with EF-Tu also reduced lung bacterial loads in mice challenged with aerosolized B. thailandensis. Our data support the utility of EF-Tu as a novel vaccine immunogen against bacterial infection. Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine against infection with this biological threat agent. In this study, we employed an immunoproteomic approach and identified bacterial Elongation factor-Tu (EF-Tu) as a potential vaccine antigen. EF-Tu is membrane-associated, secreted in outer membrane vesicles (OMVs), and immunogenic during Burkholderia infection in the murine model of melioidosis. Active immunization with EF-Tu induced antigen-specific antibody and cell-mediated immune responses in mice. Mucosal immunization with EF-Tu also reduced lung bacterial loads in mice challenged with aerosolized B. thailandensis . Our data support the utility of EF-Tu as a novel vaccine immunogen against bacterial infection. |
Audience | Academic |
Author | Nieves, Wildaliz Heang, Julie Morici, Lisa A Asakrah, Saja Roy, Chad J Höner zu Bentrup, Kerstin |
AuthorAffiliation | 2 Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America Cairo University, Egypt 1 Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America |
AuthorAffiliation_xml | – name: 1 Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America – name: 2 Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America – name: Cairo University, Egypt |
Author_xml | – sequence: 1 givenname: Wildaliz surname: Nieves fullname: Nieves, Wildaliz organization: Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America – sequence: 2 givenname: Julie surname: Heang fullname: Heang, Julie – sequence: 3 givenname: Saja surname: Asakrah fullname: Asakrah, Saja – sequence: 4 givenname: Kerstin surname: Höner zu Bentrup fullname: Höner zu Bentrup, Kerstin – sequence: 5 givenname: Chad J surname: Roy fullname: Roy, Chad J – sequence: 6 givenname: Lisa A surname: Morici fullname: Morici, Lisa A |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21179405$$D View this record in MEDLINE/PubMed |
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Copyright | COPYRIGHT 2010 Public Library of Science 2010 Nieves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Nieves et al. 2010 |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: CJR LAM. Performed the experiments: WN JH SA KHzB CJR. Analyzed the data: WN JH SA KHzB LAM. Wrote the paper: WN JH LAM. |
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Snippet | Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no... Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in parts of Southeast Asia and Northern Australia. Currently there is no... |
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SubjectTerms | Anaplasma Animal models Animals Antigens Antigens, Bacterial - chemistry Bacteria Bacterial infections Bordetella Bordetella pertussis Brucella Brucella abortus Burkholderia Infections - metabolism Burkholderia Infections - microbiology Burkholderia pseudomallei Burkholderia pseudomallei - metabolism Cell Biology Chlamydia Chlamydia pneumoniae Cloning, Molecular Electrophoresis, Gel, Two-Dimensional - methods Elongation Elongation factor EF-Tu Etiology Female Health aspects Identification Immune response (cell-mediated) Immune System Immunization Immunogenicity Immunology Immunology/Immunity to Infections Infection Infections Infectious Diseases/Bacterial Infections Lungs Medical research Medicine Melioidosis Melioidosis - microbiology Membrane vesicles Mice Mice, Inbred BALB C Microbiology/Immunity to Infections Mortality Mucosal immunity Mycobacterium Peptide Elongation Factor Tu - metabolism Prokaryotes Proteins Proteomics - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Stem Cells - metabolism Vaccines Whooping cough |
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Title | Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization |
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