Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging

• Published in: PloS one Vol. 15; no. 8; p. e0236834
• Main Authors: Shimizu, Sunao, Mimura, Junsei, Hasegawa, Takanori, Shimizu, Eigo, Imoto, Seiya, Tsushima, Michiko, Kasai, Shuya, Yamazaki, Hiromi, Ushida, Yusuke, Suganuma, Hiroyuki, Tomita, Hirofumi, Yamamoto, Masayuki, Nakaji, Shigeyuki, Itoh, Ken
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 11.08.2020; Public Library of Science (PLoS)
• Subjects: Age; Aging; Aging (Biology); Alleles; Ankle; Arteriosclerosis; Atherosclerosis; Biology and Life Sciences; Biomedical research; Blood pressure; Cardiology; Cardiovascular disease; Cardiovascular diseases; Diabetes; Endothelium; Evaluation; Funding; Gene expression; Genetic aspects; Genomes; Health aspects; Health promotion; Health risks; Heart diseases; Homeostasis; Life sciences; Mechanical properties; Medical research; Medicine; Medicine and Health Sciences; Multivariate analysis; Nephrology; NRF2 protein; Nucleotides; Oxidative stress; Physical Sciences; Physiological aspects; Proteins; Public health; Research and Analysis Methods; Risk analysis; Risk factors; Senescence; Shear stress; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Stiffness; Transcription factors; University graduates; Vascular resistance; Veins & arteries; Wave velocity; Japan

Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age and is increasingly recognized as an independent risk factor for cardiovascular disease (CVD). Although many mechanical and chemical factors underlie the stiffness of the elastic artery, genetic risk factors related to...