A Second-Generation Device for Automated Training and Quantitative Behavior Analyses of Molecularly-Tractable Model Organisms

A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 5; no. 12; p. e14370
Main Authors Blackiston, Douglas, Shomrat, Tal, Nicolas, Cindy L., Granata, Christopher, Levin, Michael
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 17.12.2010
Public Library of Science (PLoS)
Subjects
Algorithms
Animal behavior
Animals
Automation
Brain
Brain - metabolism
Caenorhabditis elegans
Central nervous system
Central Nervous System - metabolism
Cognitive ability
Computer Science/Control Technology
Computer Science/Natural and Synthetic Vision
Computer vision
Design engineering
Developmental biology
Drosophila
Electrodes
Electrophysiology - methods
Engineering
Environmental control
Ethology
Flatworms
Frogs
Genetics
Image Processing, Computer-Assisted - methods
Light
Machine vision
Models, Biological
Multidisciplinary research
Mutation
Nervous system
Neurophysiology
Neuroscience/Animal Cognition
Neuroscience/Behavioral Neuroscience
Neuroscience/Cognitive Neuroscience
Neuroscience/Experimental Psychology
Operant conditioning
Pharmacology
Planarians - metabolism
Quantitative analysis
Regenerative medicine
Software
Standardization
Technology application
Tracking systems
Training
Xenopus laevis - metabolism
Zebrafish
United States > US
Massachusetts
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0014370

Cover

Abstract A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science.
AbstractList A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science.A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science.
A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science.
A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system structure to behavior. Molecularly-tractable model systems such as Xenopus laevis and planaria offer an unprecedented opportunity to dissect the mechanisms determining the complex structure of the brain and CNS. A standardized platform that facilitated quantitative analysis of behavior would make a significant impact on evolutionary ethology, neuropharmacology, and cognitive science. While some animal tracking systems exist, the available systems do not allow automated training (feedback to individual subjects in real time, which is necessary for operant conditioning assays). The lack of standardization in the field, and the numerous technical challenges that face the development of a versatile system with the necessary capabilities, comprise a significant barrier keeping molecular developmental biology labs from integrating behavior analysis endpoints into their pharmacological and genetic perturbations. Here we report the development of a second-generation system that is a highly flexible, powerful machine vision and environmental control platform. In order to enable multidisciplinary studies aimed at understanding the roles of genes in brain function and behavior, and aid other laboratories that do not have the facilities to undergo complex engineering development, we describe the device and the problems that it overcomes. We also present sample data using frog tadpoles and flatworms to illustrate its use. Having solved significant engineering challenges in its construction, the resulting design is a relatively inexpensive instrument of wide relevance for several fields, and will accelerate interdisciplinary discovery in pharmacology, neurobiology, regenerative medicine, and cognitive science.
Audience Academic
Author Levin, Michael
Blackiston, Douglas
Granata, Christopher
Shomrat, Tal
Nicolas, Cindy L.
AuthorAffiliation 2 Department of Regenerative and Developmental Biology, Forsyth Institute, Boston, Massachusetts, United States of America
3 Boston Engineering Corporation, Waltham, Massachusetts, United States of America
University of Queensland, Australia
1 Biology Department and Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, United States of America
AuthorAffiliation_xml – name: 2 Department of Regenerative and Developmental Biology, Forsyth Institute, Boston, Massachusetts, United States of America
– name: University of Queensland, Australia
– name: 1 Biology Department and Center for Regenerative and Developmental Biology, Tufts University, Medford, Massachusetts, United States of America
– name: 3 Boston Engineering Corporation, Waltham, Massachusetts, United States of America
Author_xml – sequence: 1
  givenname: Douglas
  surname: Blackiston
  fullname: Blackiston, Douglas
– sequence: 2
  givenname: Tal
  surname: Shomrat
  fullname: Shomrat, Tal
– sequence: 3
  givenname: Cindy L.
  surname: Nicolas
  fullname: Nicolas, Cindy L.
– sequence: 4
  givenname: Christopher
  surname: Granata
  fullname: Granata, Christopher
– sequence: 5
  givenname: Michael
  surname: Levin
  fullname: Levin, Michael
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21179424$$D View this record in MEDLINE/PubMed
BookMark eNqNk9trFDEUxgep2Iv-B6IDguLDrrntXHwQ1qp1oVK01deQy5ndlGyyJpnFPvi_m2l3pVuKyDDMcOb3fcl8Oeew2HPeQVE8xWiMaY3fXPo-OGHHq1weI4QZrdGD4gC3lIwqgujerff94jDGS4QmtKmqR8U-wbhuGWEHxe9peQ7KOz06AQdBJONd-QHWRkHZ-VBO--SXIoEuL4Iwzrh5KZwuv_bCJZMyvobyPSzE2gxw3s9VhFj6rvziLajeimCvRlmqkpAWclWDLc_CXDgTl_Fx8bATNsKTzfOo-P7p48Xx59Hp2cnseHo6UjVhaYQnupOYElQJ3Kh8Ny2jAhOtZaV01UlU4VZhVlHEOpC1VpNWN42gXa2xRIIeFc9vfFfWR75JLnJM2iEdVreZmN0Q2otLvgpmKcIV98Lw64IPcy5CMsoCl0K2hKlWdlIxSWrBlOyqJp8JEIKbSfZ6t1mtl0vQClwKwu6Y7n5xZsHnfs0pQvkQaTZ4tTEI_mcPMfGliQqsFQ58H3mTz69lLcOZfHGHvP_nNtRc5P0b1_m8rBo8-ZTVtMGMkSZT43uofGlYmtwi0Jlc3xG83hFkJsGvNBd9jHx2_u3_2bMfu-zLW-wChE2L6G0_9GbcBZ_dDvpvwtv2zsDbG0AFH2OAjqvrpvVD7sZyjPgwS9vQ-DBLfDNLWczuiLf-_5T9AeWYI-o
CitedBy_id crossref_primary_10_3389_fncel_2020_00136
crossref_primary_10_1038_s41684_021_00908_7
crossref_primary_10_1371_journal_pone_0142214
crossref_primary_10_1016_j_scitotenv_2021_145577
crossref_primary_10_1002_cpz1_637
crossref_primary_10_1016_j_scitotenv_2020_143922
crossref_primary_10_1080_19420889_2015_1073424
crossref_primary_10_1021_acs_est_3c07013
crossref_primary_10_1242_jeb_074963
crossref_primary_10_1007_s13311_014_0317_7
crossref_primary_10_1016_j_isci_2022_105375
crossref_primary_10_1101_pdb_top068338
crossref_primary_10_1242_jeb_087809
crossref_primary_10_1007_s00441_012_1329_4
crossref_primary_10_1007_s10071_023_01780_3
crossref_primary_10_1063_1_5042779
crossref_primary_10_1002_reg2_79
crossref_primary_10_1007_s40614_018_00176_w
crossref_primary_10_1016_j_bbr_2011_04_033
crossref_primary_10_1016_j_anbehav_2013_05_043
crossref_primary_10_1016_j_beproc_2020_104226
crossref_primary_10_1242_bio_020149
crossref_primary_10_1016_j_compbiomed_2014_08_026
crossref_primary_10_3390_md17060340
crossref_primary_10_1242_bio_060480
crossref_primary_10_1038_s41467_018_03334_5
crossref_primary_10_1039_D3LC00488K
crossref_primary_10_1038_s41536_017_0012_5
crossref_primary_10_1002_dvg_22009
crossref_primary_10_1242_dev_086900
crossref_primary_10_1007_s10071_016_0990_5
crossref_primary_10_1080_17460441_2017_1367281
Cites_doi 10.1037/h0024808
10.1126/science.314.5806.1674
10.1101/lm.5.4.391
10.1016/S0925-4773(01)00304-5
10.1016/0031-9384(94)00214-P
10.1523/JNEUROSCI.4516-09.2010
10.1016/j.physbeh.2008.03.021
10.1097/00001756-200109170-00001
10.1016/S0960-9822(00)00495-4
10.1016/j.ntt.2009.04.066
10.1007/BF00204113
10.1016/j.ymeth.2005.12.007
10.1016/j.ntt.2004.06.016
10.1007/s00427-003-0310-3
10.1016/S0378-1119(03)00431-1
10.1128/IAI.69.3.1373-1380.2001
10.1023/B:MICS.0000006849.98007.03
10.1016/j.heares.2005.05.005
10.1002/(SICI)1097-010X(19961201)276:5<335::AID-JEZ4>3.0.CO;2-P
10.1038/ng1056
10.3758/BF03193904
10.1002/jez.1402300207
10.1038/scientificamerican0263-54
10.1016/j.npep.2008.03.005
10.1016/S0960-9822(03)00492-5
10.1080/00223980.1964.9916729
10.1038/nbt963
10.1126/science.139.3559.1048
10.1159/000087158
10.1371/journal.pgen.0010066
10.1016/j.semcdb.2009.04.005
10.1093/genetics/162.1.229
10.1006/dbio.1997.8635
10.1101/sqb.2002.67.301
10.1016/j.bbr.2008.02.028
10.1111/j.1365-2443.2006.00962.x
10.1242/jeb.203.12.1857
10.1016/0091-3057(82)90093-4
10.1098/rspb.2008.0754
10.1016/S1050-6411(00)00038-9
10.1023/A:1025762314250
10.1016/j.ydbio.2009.12.012
10.1016/j.pharmthera.2006.05.012
10.3758/BF03192800
10.1086/505769
10.1111/j.1530-0277.2008.00874.x
10.1002/etc.5620090107
10.1016/S0006-291X(02)02063-6
10.1016/0031-9384(91)90086-4
10.1016/S0006-8993(01)02444-1
10.1006/eesa.1993.1001
10.1016/j.cub.2005.03.044
10.1016/S0304-4165(01)00125-8
10.1111/j.1439-0310.2006.01295.x
10.1016/j.anbehav.2006.11.032
10.1073/pnas.191380698
10.1002/jcb.10061
10.1016/S0003-3472(81)80148-0
10.1159/000047890
10.1242/dev.041798
10.2108/zsj.21.275
10.1242/jeb.203.23.3621
10.1016/j.ejphar.2009.05.022
10.1021/ja0023377
10.1016/j.phymed.2003.12.008
10.1523/JNEUROSCI.14-05-02789.1994
10.1016/S0166-4328(97)80982-5
10.1016/j.bbr.2009.04.030
10.1038/nmeth1075
10.1016/j.neulet.2008.04.086
10.1038/209599a0
10.1186/1471-2156-6-5
10.1016/0091-3057(83)90303-9
10.1016/S0960-9822(03)00539-6
10.1002/jez.a.10247
10.1016/j.cub.2004.04.042
10.1016/j.physbeh.2007.01.023
10.1006/dbio.1999.9528
10.1016/j.ntt.2006.01.013
10.2307/1419955
10.1037/0003-066X.51.6.589
10.1007/BF01338566
10.1016/j.pbb.2006.11.010
10.1038/nature08323
10.1016/j.bbr.2007.10.031
10.1242/dev.01941
10.1016/0024-3205(74)90394-4
10.1038/2151465a0
10.1146/annurev.neuro.28.051804.101610
10.1085/jgp.51.2.255
10.1016/S0166-4328(99)00071-6
10.1038/35042526
10.1146/annurev.cellbio.20.010403.095114
10.1038/nature06189
10.2307/1564653
10.1037/h0041147
10.1002/syn.20571
10.1159/000066699
10.1016/S0166-4328(01)00167-X
10.1006/dbio.2000.9978
10.1016/j.ejphar.2008.02.018
10.1097/00001756-199810260-00020
10.2466/pr0.1996.79.3.763
10.1016/j.devcel.2004.12.017
10.1016/S0091-3057(00)00422-6
10.1111/j.1360-0443.2006.01586.x
10.1016/S0031-9384(00)00317-6
10.1523/JNEUROSCI.4332-06.2006
10.1007/BF00441080
10.1016/S0891-5849(03)00328-9
10.1016/j.bbr.2007.07.037
10.1038/nrd1606
10.1242/dev.01663
10.3758/BF03195394
10.1242/dev.123.1.399
10.1242/dev.124.23.4905
10.1016/j.nlm.2007.09.004
10.1038/ncb734
10.1038/nrg759
10.1371/journal.pbio.1000174
10.1242/dev.126.20.4513
10.1126/science.1148564
10.1016/S0165-0270(02)00118-8
10.1038/laban0506-33
10.1126/science.134.3487.1363
10.2307/1543265
10.1016/j.bbr.2009.03.003
10.1016/j.neuroscience.2006.12.073
10.1093/genetics/162.1.113
10.1038/2191227a0
10.1016/S0003-3472(71)80021-0
10.1016/0892-0362(91)90007-J
10.1006/dbio.1999.9275
10.1002/neu.20290
10.1097/FPC.0b013e3280119d62
10.1111/j.1749-6632.1998.tb09060.x
10.1007/978-1-59745-257-1_5
10.1152/jn.01248.2004
10.1126/science.146.3641.274
10.1016/S0092-8674(02)00939-X
10.1007/s10540-005-2891-8
10.1016/j.bbr.2007.12.007
10.1073/pnas.92.23.10545
10.1242/dev.00167
10.1002/dneu.20377
10.1016/S0165-0270(02)00020-1
10.1016/j.ejphar.2008.01.012
10.1037/h0044394
10.1038/273774a0
10.1038/nchembio749
10.1038/nchembio.307
10.1016/j.cub.2004.03.006
10.1242/jeb.199.12.2689
10.1016/0022-5193(67)90110-5
10.1016/j.eplepsyres.2007.03.015
10.1016/S0959-4388(00)00116-1
10.1016/j.chembiol.2003.10.003
ContentType Journal Article
Copyright COPYRIGHT 2010 Public Library of Science
2010 Blackiston et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Blackiston et al. 2010
Copyright_xml – notice: COPYRIGHT 2010 Public Library of Science
– notice: 2010 Blackiston et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Blackiston et al. 2010
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0014370
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Opposing Viewpoints Resource Center
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials Local Electronic Collection Information
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database (Proquest)
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
ProQuest Biological Science Collection
Agricultural Science Database
Health & Medical Collection (Alumni Edition)
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection (ProQuest)
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ : directory of open access journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic



MEDLINE
Agricultural Science Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Engineering
DocumentTitleAlternate Automated Analysis of Learning
EISSN 1932-6203
ExternalDocumentID 1296203479
oai_doaj_org_article_bab924c9bfbc4b27a4cbf68371e22185
PMC3003703
2898785861
A473814428
21179424
10_1371_journal_pone_0014370
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations United States--US
Massachusetts
GeographicLocations_xml – name: Massachusetts
– name: United States--US
GrantInformation_xml – fundername: NIDCR NIH HHS
  grantid: T32 DE007327
– fundername: NIDCR NIH HHS
  grantid: T32-DE-007327
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PYCSY
RIG
RNS
RPM
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
3V.
BBORY
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
RC3
7X8
ESTFP
PUEGO
5PM
AAPBV
ABPTK
N95
ID FETCH-LOGICAL-c724t-15dfb13206a18ca188943a12ddb6cd6fb0619c146304feb7dc59d88a3f7d1b0a3
IEDL.DBID M48
ISSN 1932-6203
IngestDate Sun May 07 16:28:38 EDT 2023
Wed Aug 27 01:31:18 EDT 2025
Thu Aug 21 14:11:02 EDT 2025
Fri Sep 05 09:56:45 EDT 2025
Sat Aug 23 12:45:33 EDT 2025
Tue Jun 17 21:31:59 EDT 2025
Tue Jun 10 20:32:04 EDT 2025
Fri Jun 27 04:55:11 EDT 2025
Fri Jun 27 05:09:00 EDT 2025
Thu May 22 21:20:38 EDT 2025
Wed Feb 19 02:08:42 EST 2025
Tue Jul 01 02:37:42 EDT 2025
Thu Apr 24 23:00:11 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c724t-15dfb13206a18ca188943a12ddb6cd6fb0619c146304feb7dc59d88a3f7d1b0a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Conceived and designed the experiments: DB TS ML. Performed the experiments: DB TS. Analyzed the data: DB TS CG. Contributed reagents/materials/analysis tools: CLN CG ML. Wrote the paper: DB TS ML. Designed the system and its target specs: MV.
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0014370
PMID 21179424
PQID 1296203479
PQPubID 1436336
PageCount e14370
ParticipantIDs plos_journals_1296203479
doaj_primary_oai_doaj_org_article_bab924c9bfbc4b27a4cbf68371e22185
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3003703
proquest_miscellaneous_821194941
proquest_journals_1296203479
gale_infotracmisc_A473814428
gale_infotracacademiconefile_A473814428
gale_incontextgauss_ISR_A473814428
gale_incontextgauss_IOV_A473814428
gale_healthsolutions_A473814428
pubmed_primary_21179424
crossref_citationtrail_10_1371_journal_pone_0014370
crossref_primary_10_1371_journal_pone_0014370
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2010-12-17
PublicationDateYYYYMMDD 2010-12-17
PublicationDate_xml – month: 12
  year: 2010
  text: 2010-12-17
  day: 17
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2010
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References A Roberts (ref129) 1978; 273
R Gerlai (ref32) 2000; 67
SD Prentice (ref148) 2001; 11
LN Vandenberg (ref41) 2010; 137
GV Ermakova (ref87) 1999; 126
WC Corning (ref108) 1970
A Elepfandt (ref73) 1986; 158
S Berghmans (ref31) 2007; 75
B Key (ref152) 2003; 25
ALaM Jacobson (ref107) 1962; XXV
C Hicks (ref43) 2006; 66
M Sison (ref95) 2006; 35
H Baier (ref136) 2000; 10
EK Neumann (ref147) 1992; 66
C Wyart (ref153) 2009; 461
MA Arbib (ref145) 1985; 44
BA Bensing (ref163) 2001; 69
ER Turnell (ref93) 2003; 205
WS Stephen (ref113) 1963; 5
AH Monsoro-Burq (ref80) 2005; 8
J Ninkovic (ref180) 2006; 39
J Best (ref59) 1962
SL Bass (ref35) 2008; 186
H Orii (ref110) 1999; 210
R Wassersug (ref62) 1971; 19
NL Vastenhouw (ref167) 2003; 13
R Spence (ref92) 2007; 113
ME Nuttall (ref160) 2001; 169
LC Katz (ref63) 1981; 29
K Nishimura (ref26) 2007; 67
M Rilling (ref109) 1996; 51
R Thompson (ref114) 1955; 48
CD Nichols (ref150) 2006; 112
MG Hulsey (ref10) 1991; 50
B Bert (ref2) 2008; 195
RT Peterson (ref176) 2004; 22
(ref105) 1965
P Cornwell (ref117) 1961; 3
IV Zhdanova (ref28) 2001; 903
L Al-Imari (ref34) 2008; 189
EJ Cram (ref165) 2003
PW Reddien (ref44) 2004; 20
K Hoff (ref71) 1989; 29
CC de la Cruz (ref139) 1999; 216
IA MacNeil (ref162) 2001; 3
J Delcourt (ref39) 2006; 38
JJ Essner (ref83) 2005; 132
AL Hartry (ref122) 1964; 146
A Gonzalo (ref65) 2007; 74
F Punzo (ref69) 1976; 73
MB McElligott (ref134) 2005; 66
R Creton (ref15) 2009; 203
MA Borla (ref89) 2002; 60
AS Viczian (ref78) 2009; 7
NK Tanaka (ref17) 2004; 14
A Miklosi (ref91) 2001; 122
P Gonczy (ref172) 2000; 408
ME Uretsky (ref64) 1996; 79
Z Chen (ref173) 2003; 306
AS Tseng (ref169) 2002; 162
MW Torello (ref12) 1983; 19
R Gerlai (ref33) 2006; 85
C Ton (ref186) 2005; 208
W Corning (ref119) 1961; 134
S Strickler-Shaw (ref67) 1990; 9
MS Gill (ref181) 2003; 35
KK Sadauskas (ref22) 1982; 32
R Pulak (ref156) 2006; 351
A Mathis (ref75) 2008; 275
PI Bang (ref182) 2002; 118
HM Brown (ref104) 1968; 51
GM Cahill (ref133) 1998; 9
EM Eisenstein (ref54) 1997; 82
P Goldsmith (ref98) 2001; 12
AL Jacobson (ref116) 1966; 209
SS Lee (ref168) 2003; 33
VS Valentinuzzi (ref8) 1998; 5
A Miklosi (ref90) 1999; 105
A Cheung (ref157) 2002; 4
D Kokel (ref14) 2010; 6
C Parng (ref184) 2006
RE Engeszer (ref135) 2004; 14
R Miller (ref76) 1977; 3
TD Irons (ref29) 2010; 32
MP Colaiacovo (ref170) 2002; 162
N Speedie (ref37) 2008; 188
SM Rawls (ref50) 2008; 42
WC Corning (ref23) 1968; 219
H Orii (ref111) 2003; 213
J Best (ref121) 1963
G Ungar (ref123) 1974; 14
CA MacRae (ref178) 2002; 67
SM Rawls (ref51) 2008; 584
MA Arbib (ref144) 1967; 14
AG Stephen (ref164) 2002; 296
RM Lee (ref24) 1963; 139
WC Corning (ref58) 1964; 58
Y Fernandes (ref102) 2009; 33
O Rawashdeh (ref99) 2007; 318
GF Koob (ref151) 2006; 101
MN Laurent (ref84) 1997; 124
RA Block (ref57) 1967; 215
NJ Giacomini (ref142) 2006; 28
B van Swinderen (ref1) 2010; 30
RM Costa (ref3) 2003; 13
DA Prober (ref27) 2006; 26
HB Sarnat (ref61) 1985
PH Wells (ref115) 1963; 5
S Rawls (ref49) 2008; 62
J den Hertog (ref179) 2005; 25
JD Thatcher (ref166) 2001; 229
MJ Boisvert (ref7) 2000; 71
T Moriya (ref126) 1996; 276
A Caveman (ref171) 2000; 113
PR Sanberg (ref11) 1985; 7
C Parng (ref187) 2005; 8
CR Tosh (ref149) 2006; 168
HM Stern (ref175) 2005; 1
CJ Cronin (ref18) 2005; 6
S Bretaud (ref101) 2007; 146
MA Masino (ref140) 2005; 93
LP Noldus (ref141) 2001; 33
MA Arbib (ref146) 1985
AM Lum (ref128) 1982; 17
F Fernandez de Miguel (ref13) 1989; 37
K Roe (ref120) 1963; 5
DM Nielsen (ref6) 2002; 115
JM Rick (ref138) 2000; 10
MJ Carvan 3rd (ref143) 2004; 26
T Katayama (ref161) 2001; 1526
Y Pan (ref96)
JJ Brightwell (ref4) 2008; 89
JR Fetcho (ref131) 1998; 860
S Jones (ref86) 1994; 14
GM Cahill (ref16) 2007; 362
A Elepfandt (ref74) 2000; 203
S Sacavage (ref52) 2008; 439
OR Pagan (ref53) 2009; 615
B Humphries (ref60) 1961; 3
G Miller (ref154) 2006; 314
LI Zon (ref174) 2005; 4
NH Copp (ref127) 1984; 230
RA Goodnow Jr (ref158) 2001
S Strickler-Shaw (ref66) 1991; 13
C Parng (ref185) 2006
A Sanchez Alvarado (ref112) 2002; 129
PA Newmark (ref45) 2002; 3
A Elepfandt (ref72) 1985; 72
CA MacRae (ref177) 2003; 10
AL Rowlands (ref48) 2008; 583
D Jamieson (ref124) 2000; 203
SP Pronych (ref125) 1996; 199
NJ Oviedo (ref46) 2009; 20
L Zhu (ref40) 2007; 91
T Fukumoto (ref88) 2005; 15
MW Barnett (ref81) 2001; 102
N Nascone (ref85) 1997; 189
A Jacobson (ref56) 1967; 64
N Chronis (ref19) 2007; 4
S Kuriyama (ref79) 2003; 296
DJ Schaeffer (ref47) 1993; 25
M Levin (ref82) 2002; 111
SE Brockerhoff (ref94) 1995; 92
JA Madrid (ref9) 1995; 57
C Renier (ref100) 2007; 17
KP Tiras (ref20) 1981; 31
R Gerlai (ref36) 2009; 201
R Rosenthal (ref5) 1976
MA Lopez Patino (ref30) 2008; 95
J Murphy (ref118) 1963; 5
F Punzo (ref68) 1991; 25
T Inoue (ref103) 2004; 21
PH Wells (ref55) 1967
K Koide (ref159) 2001; 123
JV McConnell (ref21) 1960; 73
K Masse (ref77) 2007; 449
NJ Oviedo (ref42) 2010; 339
F Cebria (ref106) 2005; 132
K Hoff (ref70) 1988; 14
R Gerlai (ref130) 2003; 33
M Granato (ref132) 1996; 123
E Fusaoka (ref25) 2006; 11
R Blaser (ref38) 2006; 38
A Muto (ref137) 2005; 1
T Darland (ref97) 2001; 98
G Miesenbock (ref155) 2005; 28
A Russo (ref183) 2005; 12
References_xml – volume: 64
  start-page: 73
  year: 1967
  ident: ref56
  article-title: Classical conditioning, pseudoconditioning, or sensitization in the planarian.
  publication-title: Journal of Comparative & Physiological Psychology
  doi: 10.1037/h0024808
– volume: 314
  start-page: 1674
  year: 2006
  ident: ref154
  article-title: Optogenetics. Shining new light on neural circuits.
  publication-title: Science
  doi: 10.1126/science.314.5806.1674
– volume: 5
  start-page: 391
  year: 1998
  ident: ref8
  article-title: Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F2 mice.
  publication-title: Learn Mem
  doi: 10.1101/lm.5.4.391
– volume: 102
  start-page: 157
  year: 2001
  ident: ref81
  article-title: Xenopus Enhancer of Zeste (XEZ); an anteriorly restricted polycomb gene with a role in neural patterning.
  publication-title: Mech Dev
  doi: 10.1016/S0925-4773(01)00304-5
– ident: ref96
  article-title: Chronic alcohol exposure induced gene expression changes in the zebrafish brain.
  publication-title: Behav Brain Res
– volume: 57
  start-page: 129
  year: 1995
  ident: ref9
  article-title: A contact eatometer for automated continuous recording of feeding behavior in rats.
  publication-title: Physiol Behav
  doi: 10.1016/0031-9384(94)00214-P
– volume: 30
  start-page: 1003
  year: 2010
  ident: ref1
  article-title: Attention-like deficit and hyperactivity in a Drosophila memory mutant.
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4516-09.2010
– volume: 95
  start-page: 36
  year: 2008
  ident: ref30
  article-title: Gender differences in zebrafish responses to cocaine withdrawal.
  publication-title: Physiol Behav
  doi: 10.1016/j.physbeh.2008.03.021
– volume: 12
  start-page: A73
  year: 2001
  ident: ref98
  article-title: Modelling eye diseases in zebrafish.
  publication-title: Neuroreport
  doi: 10.1097/00001756-200109170-00001
– volume: 10
  start-page: 595
  year: 2000
  ident: ref138
  article-title: Optokinetic behavior is reversed in achiasmatic mutant zebrafish larvae.
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(00)00495-4
– volume: 8
  start-page: 100
  year: 2005
  ident: ref187
  article-title: In vivo zebrafish assays for toxicity testing.
  publication-title: Curr Opin Drug Discov Devel
– volume: 32
  start-page: 84
  year: 2010
  ident: ref29
  article-title: Acute neuroactive drug exposures alter locomotor activity in larval zebrafish.
  publication-title: Neurotoxicol Teratol
  doi: 10.1016/j.ntt.2009.04.066
– volume: 66
  start-page: 485
  year: 1992
  ident: ref147
  article-title: Artificial neural network classification of Drosophila courtship song mutants.
  publication-title: Biol Cybern
  doi: 10.1007/BF00204113
– volume: 39
  start-page: 262
  year: 2006
  ident: ref180
  article-title: The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse.
  publication-title: Methods
  doi: 10.1016/j.ymeth.2005.12.007
– volume: 26
  start-page: 757
  year: 2004
  ident: ref143
  article-title: Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis.
  publication-title: Neurotoxicol Teratol
  doi: 10.1016/j.ntt.2004.06.016
– volume: 213
  start-page: 138
  year: 2003
  ident: ref111
  article-title: A simple "soaking method" for RNA interference in the planarian Dugesia japonica.
  publication-title: Dev Genes Evol
  doi: 10.1007/s00427-003-0310-3
– volume: 306
  start-page: 127
  year: 2003
  ident: ref173
  article-title: A highly efficient and sensitive screening method for trans-activation activity of estrogen receptors.
  publication-title: Gene
  doi: 10.1016/S0378-1119(03)00431-1
– volume: 69
  start-page: 1373
  year: 2001
  ident: ref163
  article-title: Genetic loci of Streptococcus mitis that mediate binding to human platelets.
  publication-title: Infection & Immunity
  doi: 10.1128/IAI.69.3.1373-1380.2001
– volume: 7
  start-page: 87
  year: 1985
  ident: ref11
  article-title: Automated measurement of multivariate locomotor behavior in rodents.
  publication-title: Neurobehav Toxicol Teratol
– volume: 3
  start-page: 301
  year: 2001
  ident: ref162
  article-title: Expression and isolation of antimicrobial small molecules from soil DNA libraries.
  publication-title: Journal of Molecular Microbiology & Biotechnology
– year: 2006
  ident: ref185
  article-title: A zebrafish assay for identifying neuroprotectants in vivo.
  publication-title: Neurotoxicol Teratol
– volume: 25
  start-page: 1
  year: 2003
  ident: ref152
  article-title: Zebrafish as an experimental model: strategies for developmental and molecular neurobiology studies.
  publication-title: Methods Cell Sci
  doi: 10.1023/B:MICS.0000006849.98007.03
– volume: 113
  start-page: 3543
  issue: Pt 20
  year: 2000
  ident: ref171
  article-title: "I'll have a genome with chips, please".
  publication-title: J Cell Sci
– volume: 208
  start-page: 79
  year: 2005
  ident: ref186
  article-title: The use of zebrafish for assessing ototoxic and otoprotective agents.
  publication-title: Hear Res
  doi: 10.1016/j.heares.2005.05.005
– volume: 276
  start-page: 335
  year: 1996
  ident: ref126
  article-title: Preference for background color of the Xenopus laevis tadpole.
  publication-title: J Exp Zool
  doi: 10.1002/(SICI)1097-010X(19961201)276:5<335::AID-JEZ4>3.0.CO;2-P
– volume: 33
  start-page: 40
  year: 2003
  ident: ref168
  article-title: A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
  publication-title: Nat Genet
  doi: 10.1038/ng1056
– volume: 38
  start-page: 704
  year: 2006
  ident: ref39
  article-title: Comparing the EthoVision 2.3 system and a new computerized multitracking prototype system to measure the swimming behavior in fry fish.
  publication-title: Behav Res Methods
  doi: 10.3758/BF03193904
– volume: 230
  start-page: 219
  year: 1984
  ident: ref127
  article-title: Effects of light-deprivation on development of photopositive behavior in Xenopus laevis tadpoles.
  publication-title: J Exp Zool
  doi: 10.1002/jez.1402300207
– volume: 5
  start-page: 16
  year: 1963
  ident: ref120
  article-title: In search of the locus of learning in planarians.
  publication-title: Worm Runner's Digest
– year: 1963
  ident: ref121
  article-title: Protopsychology.
  doi: 10.1038/scientificamerican0263-54
– volume: 42
  start-page: 229
  year: 2008
  ident: ref50
  article-title: Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians.
  publication-title: Neuropeptides
  doi: 10.1016/j.npep.2008.03.005
– volume: 13
  start-page: 1348
  year: 2003
  ident: ref3
  article-title: Learning and memory deficits in Notch mutant mice.
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(03)00492-5
– volume: 58
  start-page: 131
  year: 1964
  ident: ref58
  article-title: Evidence of right-left discrimination in planarians.
  publication-title: The Journal of Psychology
  doi: 10.1080/00223980.1964.9916729
– volume: 22
  start-page: 595
  year: 2004
  ident: ref176
  article-title: Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt963
– volume: 139
  start-page: 1048
  year: 1963
  ident: ref24
  article-title: Conditioning of a free operant response in planaria.
  publication-title: Science
  doi: 10.1126/science.139.3559.1048
– volume: 66
  start-page: 177
  year: 2005
  ident: ref134
  article-title: Prey tracking by larval zebrafish: axial kinematics and visual control.
  publication-title: Brain Behav Evol
  doi: 10.1159/000087158
– start-page: xii, 156
  year: 1985
  ident: ref146
  article-title: In search of the person: philosophical explorations in cognitive science.
– volume: 1
  start-page: e66
  year: 2005
  ident: ref137
  article-title: Forward genetic analysis of visual behavior in zebrafish.
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0010066
– volume: 20
  start-page: 557
  year: 2009
  ident: ref46
  article-title: Regeneration: The origin of cancer or a possible cure?
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2009.04.005
– volume: 162
  start-page: 229
  year: 2002
  ident: ref169
  article-title: An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye.
  publication-title: Genetics
  doi: 10.1093/genetics/162.1.229
– volume: 32
  start-page: 1176
  year: 1982
  ident: ref22
  article-title: [Method of recording the actograms of small aquatic animals and primary automatic processing of the information].
  publication-title: Zh Vyssh Nerv Deiat Im I P Pavlova
– volume: 189
  start-page: 68
  year: 1997
  ident: ref85
  article-title: Organizer induction determines left-right asymmetry in Xenopus.
  publication-title: Dev Biol
  doi: 10.1006/dbio.1997.8635
– volume: 67
  start-page: 301
  year: 2002
  ident: ref178
  article-title: Zebrafish: the complete cardiovascular compendium.
  publication-title: Cold Spring Harb Symp Quant Biol
  doi: 10.1101/sqb.2002.67.301
– volume: 195
  start-page: 78
  year: 2008
  ident: ref2
  article-title: Learning and memory in 5-HT(1A)-receptor mutant mice.
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2008.02.028
– volume: 5
  start-page: 37
  year: 1963
  ident: ref118
  article-title: Learning in the planarian.
  publication-title: Worm Runner's Digest
– volume: 11
  start-page: 541
  year: 2006
  ident: ref25
  article-title: Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian.
  publication-title: Genes Cells
  doi: 10.1111/j.1365-2443.2006.00962.x
– volume: 203
  start-page: 1857
  issue: Pt 12
  year: 2000
  ident: ref124
  article-title: Responses of young Xenopus laevis tadpoles to light dimming: possible roles for the pineal eye.
  publication-title: J Exp Biol
  doi: 10.1242/jeb.203.12.1857
– volume: 17
  start-page: 363
  year: 1982
  ident: ref128
  article-title: Schooling behavior of tadpoles: a potential indicator of ototoxicity.
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/0091-3057(82)90093-4
– volume: 275
  start-page: 2603
  year: 2008
  ident: ref75
  article-title: Learning by embryos and the ghost of predation future.
  publication-title: Proc Biol Sci
  doi: 10.1098/rspb.2008.0754
– volume: 11
  start-page: 19
  year: 2001
  ident: ref148
  article-title: Artificial neural network model for the generation of muscle activation patterns for human locomotion.
  publication-title: J Electromyogr Kinesiol
  doi: 10.1016/S1050-6411(00)00038-9
– volume: 33
  start-page: 461
  year: 2003
  ident: ref130
  article-title: Zebra fish: an uncharted behavior genetic model.
  publication-title: Behav Genet
  doi: 10.1023/A:1025762314250
– volume: 339
  start-page: 188
  year: 2010
  ident: ref42
  article-title: Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration.
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2009.12.012
– volume: 112
  start-page: 677
  year: 2006
  ident: ref150
  article-title: Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery.
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2006.05.012
– volume: 38
  start-page: 456
  year: 2006
  ident: ref38
  article-title: Behavioral phenotyping in zebrafish: comparison of three behavioral quantification methods.
  publication-title: Behav Res Methods
  doi: 10.3758/BF03192800
– volume: 31
  start-page: 874
  year: 1981
  ident: ref20
  article-title: Device for the graphic recording of planaria behavior.
  publication-title: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova
– volume: 168
  start-page: E38
  year: 2006
  ident: ref149
  article-title: Artificial neural network properties associated with wiring patterns in the visual projections of vertebrates and arthropods.
  publication-title: Am Nat
  doi: 10.1086/505769
– volume: 33
  start-page: 601
  year: 2009
  ident: ref102
  article-title: Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish.
  publication-title: Alcohol Clin Exp Res
  doi: 10.1111/j.1530-0277.2008.00874.x
– volume: 9
  start-page: 47
  year: 1990
  ident: ref67
  article-title: Sublethal exposure to lead inhibits acquisition and retention of discriminate avoidance learning in green frog (Rana clamitans) tadpoles.
  publication-title: Environ Toxicol Chem
  doi: 10.1002/etc.5620090107
– start-page: 251
  year: 1967
  ident: ref55
  article-title: Training flatworms in a Van Oye maze.
– volume: 3
  start-page: 91
  year: 1961
  ident: ref117
  article-title: An attempted replication of studies by Halas, et al. and by Thompson and McConnell.
  publication-title: Worm Runner's Digest
– volume: 296
  start-page: 1228
  year: 2002
  ident: ref164
  article-title: Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity.
  publication-title: Biochemical & Biophysical Research Communications
  doi: 10.1016/S0006-291X(02)02063-6
– volume: 50
  start-page: 403
  year: 1991
  ident: ref10
  article-title: A system for automated recording and analysis of feeding behavior.
  publication-title: Physiol Behav
  doi: 10.1016/0031-9384(91)90086-4
– volume: 37
  start-page: 71
  year: 1989
  ident: ref13
  article-title: An automated system for detection and analysis of locomotor behavior in crustaceans.
  publication-title: Bol Estud Med Biol
– volume: 903
  start-page: 263
  year: 2001
  ident: ref28
  article-title: Melatonin promotes sleep-like state in zebrafish.
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(01)02444-1
– volume: 25
  start-page: 1
  year: 1993
  ident: ref47
  article-title: Planarians as a model system for in vivo tumorigenesis studies.
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1006/eesa.1993.1001
– volume: 15
  start-page: 794
  year: 2005
  ident: ref88
  article-title: Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos.
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2005.03.044
– volume: 1526
  start-page: 183
  year: 2001
  ident: ref161
  article-title: Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin.
  publication-title: Biochimica et Biophysica Acta
  doi: 10.1016/S0304-4165(01)00125-8
– volume: 113
  start-page: 62
  year: 2007
  ident: ref92
  article-title: The role of early learning in determining shoaling preferences based on visual cues in the zebrafish, Danio rerio.
  publication-title: Ethology
  doi: 10.1111/j.1439-0310.2006.01295.x
– volume: 74
  start-page: 447
  year: 2007
  ident: ref65
  article-title: Iberian green frog tadpoles may learn to recognize novel predators from chemical alarm cues of conspecifics.
  publication-title: Animal Behaviour
  doi: 10.1016/j.anbehav.2006.11.032
– volume: 98
  start-page: 11691
  year: 2001
  ident: ref97
  article-title: Behavioral screening for cocaine sensitivity in mutagenized zebrafish.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.191380698
– start-page: 13
  year: 2001
  ident: ref158
  article-title: Current practices in generation of small molecule new leads.
  publication-title: Journal of Cellular Biochemistry - Supplement
  doi: 10.1002/jcb.10061
– volume: 29
  start-page: 20
  year: 1981
  ident: ref63
  article-title: Structure and mechanisms of schooling in tadpoles of the clawed frog, Xenopus laevis.
  publication-title: Animal Behaviour
  doi: 10.1016/S0003-3472(81)80148-0
– volume: 169
  start-page: 265
  year: 2001
  ident: ref160
  article-title: Drug discovery and target validation.
  publication-title: Cells Tissues Organs
  doi: 10.1159/000047890
– volume: 351
  start-page: 275
  year: 2006
  ident: ref156
  article-title: Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system.
  publication-title: Methods Mol Biol
– volume: 137
  start-page: 1095
  year: 2010
  ident: ref41
  article-title: Consistent left-right asymmetry cannot be established by late organizers in Xenopus unless the late organizer is a conjoined twin.
  publication-title: Development
  doi: 10.1242/dev.041798
– volume: 21
  start-page: 275
  year: 2004
  ident: ref103
  article-title: Morphological and functional recovery of the planarian photosensing system during head regeneration.
  publication-title: Zoolog Sci
  doi: 10.2108/zsj.21.275
– volume: 203
  start-page: 3621
  year: 2000
  ident: ref74
  article-title: Hearing threshold and frequency discrimination in the purely aquatic frog Xenopus laevis (pipidae): Measurement by means of conditioning.
  publication-title: Journal of Experimental Biology
  doi: 10.1242/jeb.203.23.3621
– volume: 615
  start-page: 118
  year: 2009
  ident: ref53
  article-title: A cembranoid from tobacco prevents the expression of nicotine-induced withdrawal behavior in planarian worms.
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2009.05.022
– volume: 123
  start-page: 398
  year: 2001
  ident: ref159
  article-title: A synthetic library of cell-permeable molecules.
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/ja0023377
– volume: 12
  start-page: 305
  year: 2005
  ident: ref183
  article-title: Bacopa monniera, a reputed nootropic plant: an overview.
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2003.12.008
– volume: 14
  start-page: 2789
  year: 1994
  ident: ref86
  article-title: Overexpression of a potassium channel gene perturbs neural differentiation.
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.14-05-02789.1994
– volume: 82
  start-page: 121
  year: 1997
  ident: ref54
  article-title: Selecting a model system for neurobiological studies of learning and memory.
  publication-title: Behav Brain Res
  doi: 10.1016/S0166-4328(97)80982-5
– volume: 203
  start-page: 127
  year: 2009
  ident: ref15
  article-title: Automated analysis of behavior in zebrafish larvae.
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2009.04.030
– volume: 4
  start-page: 727
  year: 2007
  ident: ref19
  article-title: Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans.
  publication-title: Nat Methods
  doi: 10.1038/nmeth1075
– volume: 439
  start-page: 84
  year: 2008
  ident: ref52
  article-title: Withdrawal-like behavior in planarians is dependent on drug exposure duration.
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.04.086
– volume: 209
  start-page: 599
  year: 1966
  ident: ref116
  article-title: Planarians and memory.
  publication-title: Nature
  doi: 10.1038/209599a0
– volume: 6
  start-page: 5
  year: 2005
  ident: ref18
  article-title: An automated system for measuring parameters of nematode sinusoidal movement.
  publication-title: BMC Genet
  doi: 10.1186/1471-2156-6-5
– volume: 19
  start-page: 13
  year: 1983
  ident: ref12
  article-title: An automated method for measurement of circling behavior in the mouse.
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/0091-3057(83)90303-9
– volume: 13
  start-page: 1311
  year: 2003
  ident: ref167
  article-title: A Genome-Wide Screen Identifies 27 Genes Involved in Transposon Silencing in C. elegans.
  publication-title: Curr Biol
  doi: 10.1016/S0960-9822(03)00539-6
– volume: 296
  start-page: 108
  year: 2003
  ident: ref79
  article-title: Xerl is a secreted protein required for establishing the neural plate/neural crest boundary in Xenopus embryo.
  publication-title: J Exp Zool A Comp Exp Biol
  doi: 10.1002/jez.a.10247
– volume: 14
  start-page: 881
  year: 2004
  ident: ref135
  article-title: Learned social preference in zebrafish.
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2004.04.042
– volume: 91
  start-page: 106
  year: 2007
  ident: ref40
  article-title: Catadioptric stereo-vision system for the real-time monitoring of 3D behavior in aquatic animals.
  publication-title: Physiol Behav
  doi: 10.1016/j.physbeh.2007.01.023
– volume: 216
  start-page: 595
  year: 1999
  ident: ref139
  article-title: Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development.
  publication-title: Dev Biol
  doi: 10.1006/dbio.1999.9528
– volume: 28
  start-page: 245
  year: 2006
  ident: ref142
  article-title: Antipsychotics produce locomotor impairment in larval zebrafish.
  publication-title: Neurotoxicol Teratol
  doi: 10.1016/j.ntt.2006.01.013
– volume: 73
  start-page: 618
  year: 1960
  ident: ref21
  article-title: An apparatus for conditioning planaria.
  publication-title: American Journal of Psychology
  doi: 10.2307/1419955
– volume: 51
  start-page: 589
  year: 1996
  ident: ref109
  article-title: The mystery of the vanished citations: James McConnell's forgotten 1960s quest for planarian learning, a biochemical engram, and celebrity.
  publication-title: American Psychologist
  doi: 10.1037/0003-066X.51.6.589
– volume: 158
  start-page: 235
  year: 1986
  ident: ref73
  article-title: Wave frequency recognition and absolute pitch for water-waves in the clawed frog, Xenopus laevis.
  publication-title: Journal of Comparative Physiology a-Sensory Neural and Behavioral Physiology
  doi: 10.1007/BF01338566
– volume: 44
  start-page: 2956
  year: 1985
  ident: ref145
  article-title: Rana computatrix: progress report, 1984.
  publication-title: Fed Proc
– volume: 85
  start-page: 752
  year: 2006
  ident: ref33
  article-title: Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio).
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2006.11.010
– volume: 14
  start-page: 692-
  year: 1988
  ident: ref70
  article-title: Frogs have short term memory of obstacles.
  publication-title: Society of Neuroscience Abstracts
– volume: 461
  start-page: 407
  year: 2009
  ident: ref153
  article-title: Optogenetic dissection of a behavioural module in the vertebrate spinal cord.
  publication-title: Nature
  doi: 10.1038/nature08323
– volume: 188
  start-page: 168
  year: 2008
  ident: ref37
  article-title: Alarm substance induced behavioral responses in zebrafish (Danio rerio).
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2007.10.031
– volume: 132
  start-page: 3691
  year: 2005
  ident: ref106
  article-title: Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture.
  publication-title: Development
  doi: 10.1242/dev.01941
– volume: 14
  start-page: 595
  year: 1974
  ident: ref123
  article-title: Molecular Coding of Memory.
  publication-title: Life Sciences
  doi: 10.1016/0024-3205(74)90394-4
– volume: 215
  start-page: 1465
  year: 1967
  ident: ref57
  article-title: Classically conditioned discrimination in the planarian, Dugesia dorotocephala.
  publication-title: Nature
  doi: 10.1038/2151465a0
– volume: 28
  start-page: 533
  year: 2005
  ident: ref155
  article-title: Optical imaging and control of genetically designated neurons in functioning circuits.
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.28.051804.101610
– year: 2006
  ident: ref184
  article-title: Neurotoxicity assessment using zebrafish.
  publication-title: J Pharmacol Toxicol Methods
– volume: 3
  start-page: 343
  year: 1977
  ident: ref76
  article-title: Retention over metamorphosis in the African claw-toed frog.
  publication-title: Journal of Experimental Psycology
– year: 1965
  ident: ref105
  article-title: A Manual of Psychological Experimentation on Planarians. 1 ed.
– volume: 51
  start-page: 255
  year: 1968
  ident: ref104
  article-title: Spectral sensitivity of the planarian ocellus.
  publication-title: Journal of General Physiology
  doi: 10.1085/jgp.51.2.255
– volume: 105
  start-page: 199
  year: 1999
  ident: ref90
  article-title: Right eye use associated with decision to bite in zebrafish.
  publication-title: Behav Brain Res
  doi: 10.1016/S0166-4328(99)00071-6
– volume: 408
  start-page: 331
  year: 2000
  ident: ref172
  article-title: Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
  publication-title: Nature
  doi: 10.1038/35042526
– volume: 20
  start-page: 725
  year: 2004
  ident: ref44
  article-title: Fundamentals of planarian regeneration.
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.20.010403.095114
– volume: 449
  start-page: 1058
  year: 2007
  ident: ref77
  article-title: Purine-mediated signalling triggers eye development.
  publication-title: Nature
  doi: 10.1038/nature06189
– volume: 25
  start-page: 214
  year: 1991
  ident: ref68
  article-title: Group learning in tadpoles of Rana heckscheri.
  publication-title: Journal of Herpetology
  doi: 10.2307/1564653
– volume: 48
  start-page: 65
  year: 1955
  ident: ref114
  article-title: Classical conditioning in the planarian Dugesia dorotocephala.
  publication-title: Journal of comparative and physiological psychology
  doi: 10.1037/h0041147
– volume: 62
  start-page: 927
  year: 2008
  ident: ref49
  article-title: Agmatine: identification and inhibition of methamphetamine, kappa opioid, and cannabinoid withdrawal in planarians.
  publication-title: Synapse
  doi: 10.1002/syn.20571
– volume: 60
  start-page: 207
  year: 2002
  ident: ref89
  article-title: Prey capture by larval zebrafish: evidence for fine axial motor control.
  publication-title: Brain Behav Evol
  doi: 10.1159/000066699
– volume: 122
  start-page: 57
  year: 2001
  ident: ref91
  article-title: Role of right hemifield in visual control of approach to target in zebrafish.
  publication-title: Behav Brain Res
  doi: 10.1016/S0166-4328(01)00167-X
– volume: 229
  start-page: 480
  year: 2001
  ident: ref166
  article-title: The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut.
  publication-title: Dev Biol
  doi: 10.1006/dbio.2000.9978
– volume: 584
  start-page: 278
  year: 2008
  ident: ref51
  article-title: The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians.
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.02.018
– volume: 9
  start-page: 3445
  year: 1998
  ident: ref133
  article-title: Circadian rhythmicity in the locomotor activity of larval zebrafish.
  publication-title: Neuroreport
  doi: 10.1097/00001756-199810260-00020
– volume: 79
  start-page: 763
  year: 1996
  ident: ref64
  article-title: Problems of conditioning Xenopus laevis tadpoles with standard avoidance-response learning paradigms.
  publication-title: Psychol Rep
  doi: 10.2466/pr0.1996.79.3.763
– volume: 8
  start-page: 167
  year: 2005
  ident: ref80
  article-title: Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2004.12.017
– volume: 67
  start-page: 773
  year: 2000
  ident: ref32
  article-title: Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects.
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/S0091-3057(00)00422-6
– start-page: 107
  year: 1970
  ident: ref108
  article-title: The planarian controversy.
– volume: 101
  start-page: 23
  year: 2006
  ident: ref151
  article-title: The neurobiology of addiction: a neuroadaptational view relevant for diagnosis.
  publication-title: Addiction
  doi: 10.1111/j.1360-0443.2006.01586.x
– volume: 71
  start-page: 147
  year: 2000
  ident: ref7
  article-title: A system for the automated recording of feeding behavior and body weight.
  publication-title: Physiol Behav
  doi: 10.1016/S0031-9384(00)00317-6
– volume: 26
  start-page: 13400
  year: 2006
  ident: ref27
  article-title: Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish.
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4332-06.2006
– volume: 72
  start-page: 492
  year: 1985
  ident: ref72
  article-title: Naturalistic conditioning reveals good learning in a frog (Xenopus laevis).
  publication-title: Naturwissenschaften
  doi: 10.1007/BF00441080
– volume: 35
  start-page: 558
  year: 2003
  ident: ref181
  article-title: An automated high-throughput assay for survival of the nematode Caenorhabditis elegans.
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(03)00328-9
– year: 1985
  ident: ref61
  article-title: The brain of the planarian as the ancestor of the human brain.
  publication-title: Canadian Journal of Neurological Sciences
– volume: 186
  start-page: 107
  year: 2008
  ident: ref35
  article-title: Zebrafish (Danio rerio) responds differentially to stimulus fish: the effects of sympatric and allopatric predators and harmless fish.
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2007.07.037
– volume: 4
  start-page: 35
  year: 2005
  ident: ref174
  article-title: In vivo drug discovery in the zebrafish.
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd1606
– volume: 132
  start-page: 1247
  year: 2005
  ident: ref83
  article-title: Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut.
  publication-title: Development
  doi: 10.1242/dev.01663
– volume: 33
  start-page: 398
  year: 2001
  ident: ref141
  article-title: EthoVision: a versatile video tracking system for automation of behavioral experiments.
  publication-title: Behav Res Methods Instrum Comput
  doi: 10.3758/BF03195394
– volume: 123
  start-page: 399
  year: 1996
  ident: ref132
  article-title: Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva.
  publication-title: Development
  doi: 10.1242/dev.123.1.399
– volume: 124
  start-page: 4905
  year: 1997
  ident: ref84
  article-title: The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer.
  publication-title: Development
  doi: 10.1242/dev.124.23.4905
– volume: 89
  start-page: 27
  year: 2008
  ident: ref4
  article-title: Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning.
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2007.09.004
– volume: 4
  start-page: 83
  year: 2002
  ident: ref157
  article-title: A small-molecule inhibitor of skeletal muscle myosin II.
  publication-title: Nature Cell Biology
  doi: 10.1038/ncb734
– volume: 3
  start-page: 210
  year: 2002
  ident: ref45
  article-title: Not your father's planarian: a classic model enters the era of functional genomics.
  publication-title: Nature Reviews Genetics
  doi: 10.1038/nrg759
– volume: 7
  start-page: e1000174
  year: 2009
  ident: ref78
  article-title: Generation of functional eyes from pluripotent cells.
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1000174
– volume: 126
  start-page: 4513
  year: 1999
  ident: ref87
  article-title: The homeobox gene, Xanf-1, can control both neural differentiation and patterning in the presumptive anterior neurectoderm of the Xenopus laevis embryo.
  publication-title: Development
  doi: 10.1242/dev.126.20.4513
– volume: 318
  start-page: 1144
  year: 2007
  ident: ref99
  article-title: Melatonin suppresses nighttime memory formation in zebrafish.
  publication-title: Science
  doi: 10.1126/science.1148564
– volume: 118
  start-page: 177
  year: 2002
  ident: ref182
  article-title: High-throughput behavioral screening method for detecting auditory response defects in zebrafish.
  publication-title: J Neurosci Methods
  doi: 10.1016/S0165-0270(02)00118-8
– volume: 35
  start-page: 33
  year: 2006
  ident: ref95
  article-title: Fishing for genes influencing vertebrate behavior: zebrafish making headway.
  publication-title: Lab Anim (NY)
  doi: 10.1038/laban0506-33
– volume: 134
  start-page: 1363
  year: 1961
  ident: ref119
  article-title: Effect of ribonuclease on retention of conditioned response in regenerated planarians.
  publication-title: Science
  doi: 10.1126/science.134.3487.1363
– volume: 205
  start-page: 225
  year: 2003
  ident: ref93
  article-title: Mate choice in zebrafish (Danio rerio) analyzed with video-stimulus techniques.
  publication-title: Biol Bull
  doi: 10.2307/1543265
– volume: 201
  start-page: 318
  year: 2009
  ident: ref36
  article-title: Zebrafish (Danio rerio) responds to the animated image of a predator: towards the development of an automated aversive task.
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2009.03.003
– volume: 146
  start-page: 1109
  year: 2007
  ident: ref101
  article-title: A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish.
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.12.073
– start-page: xiii, 500
  year: 1976
  ident: ref5
  article-title: Experimenter effects in behavioral research.
– volume: 73
  start-page: 270
  year: 1976
  ident: ref69
  article-title: The effects of early experience on habitat selection in tadpoles.
  publication-title: Journal of the Bombay Natural Historical Society
– volume: 162
  start-page: 113
  year: 2002
  ident: ref170
  article-title: A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline.
  publication-title: Genetics
  doi: 10.1093/genetics/162.1.113
– volume: 219
  start-page: 1227
  year: 1968
  ident: ref23
  article-title: Planarian behaviour and biochemistry.
  publication-title: Nature
  doi: 10.1038/2191227a0
– volume: 19
  start-page: 386
  year: 1971
  ident: ref62
  article-title: Tadpole behaviour: Aggregation in larval Xenopus laevis.
  publication-title: Animal Behaviour
  doi: 10.1016/S0003-3472(71)80021-0
– volume: 13
  start-page: 167
  year: 1991
  ident: ref66
  article-title: Lead inhibits acquisition and retention learning in bullfrog tadpoles.
  publication-title: Neurotoxicol Teratol
  doi: 10.1016/0892-0362(91)90007-J
– volume: 210
  start-page: 456
  year: 1999
  ident: ref110
  article-title: The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis.
  publication-title: Dev Biol
  doi: 10.1006/dbio.1999.9275
– volume: 66
  start-page: 977
  year: 2006
  ident: ref43
  article-title: Automated analysis of behavior: A computer-controlled system for drug screening and the investigation of learning.
  publication-title: J Neurobiol
  doi: 10.1002/neu.20290
– volume: 17
  start-page: 237
  year: 2007
  ident: ref100
  article-title: Genomic and functional conservation of sedative-hypnotic targets in the zebrafish.
  publication-title: Pharmacogenet Genomics
  doi: 10.1097/FPC.0b013e3280119d62
– volume: 860
  start-page: 333
  year: 1998
  ident: ref131
  article-title: Zebrafish as a model system for studying neuronal circuits and behavior.
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.1998.tb09060.x
– volume: 362
  start-page: 83
  year: 2007
  ident: ref16
  article-title: Automated video image analysis of larval zebrafish locomotor rhythms.
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-59745-257-1_5
– volume: 93
  start-page: 3177
  year: 2005
  ident: ref140
  article-title: Fictive swimming motor patterns in wild type and mutant larval zebrafish.
  publication-title: J Neurophysiol
  doi: 10.1152/jn.01248.2004
– volume: 146
  start-page: 274
  year: 1964
  ident: ref122
  article-title: Planaria - Memory Transfer through Cannibalism Reexamined.
  publication-title: Science
  doi: 10.1126/science.146.3641.274
– year: 2003
  ident: ref165
  article-title: Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans.
  publication-title: J Cell Sci Pt
– volume: 111
  start-page: 77
  year: 2002
  ident: ref82
  article-title: Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning.
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00939-X
– volume: XXV
  start-page: 25
  year: 1962
  ident: ref107
  article-title: Research on learning in the planarian.
  publication-title: Carolina Tips
– volume: 5
  start-page: 58
  year: 1963
  ident: ref115
  article-title: Experiments on conditions of learning in planarian flatworms.
  publication-title: Worm Runner's Digest
– volume: 25
  start-page: 289
  year: 2005
  ident: ref179
  article-title: Chemical genetics: Drug screens in Zebrafish.
  publication-title: Biosci Rep
  doi: 10.1007/s10540-005-2891-8
– volume: 5
  start-page: 40
  year: 1963
  ident: ref113
  article-title: The influence of varying light intensities on speed of movement in Planaria Lugubris.
  publication-title: Worm Runner's Digest
– volume: 189
  start-page: 216
  year: 2008
  ident: ref34
  article-title: Sight of conspecifics as reward in associative learning in zebrafish (Danio rerio).
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2007.12.007
– volume: 92
  start-page: 10545
  year: 1995
  ident: ref94
  article-title: A behavioral screen for isolating zebrafish mutants with visual system defects.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.23.10545
– volume: 129
  start-page: 5659
  year: 2002
  ident: ref112
  article-title: The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration.
  publication-title: Development
  doi: 10.1242/dev.00167
– volume: 67
  start-page: 1059
  year: 2007
  ident: ref26
  article-title: Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates.
  publication-title: Dev Neurobiol
  doi: 10.1002/dneu.20377
– volume: 115
  start-page: 199
  year: 2002
  ident: ref6
  article-title: Automated analysis of foot-shock sensitivity and concurrent freezing behavior in mice.
  publication-title: J Neurosci Methods
  doi: 10.1016/S0165-0270(02)00020-1
– volume: 583
  start-page: 170
  year: 2008
  ident: ref48
  article-title: Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.01.012
– start-page: 560
  year: 1962
  ident: ref59
  article-title: Maze leaning and associated behavior in Planaria.
  publication-title: Journal of Comparative & Physiological Psychology
  doi: 10.1037/h0044394
– volume: 273
  start-page: 774
  year: 1978
  ident: ref129
  article-title: Pineal eye and behaviour in Xenopus tadpoles.
  publication-title: Nature
  doi: 10.1038/273774a0
– volume: 29
  start-page: 43
  year: 1989
  ident: ref71
  article-title: Changes in evasive maneuvers during metamprphosis in bullfrogs.
  publication-title: American Zoologist
– volume: 1
  start-page: 366
  year: 2005
  ident: ref175
  article-title: Small molecules that delay S phase suppress a zebrafish bmyb mutant.
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio749
– volume: 6
  start-page: 231
  year: 2010
  ident: ref14
  article-title: Rapid behavior-based identification of neuroactive small molecules in the zebrafish.
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.307
– volume: 3
  start-page: 114
  year: 1961
  ident: ref60
  article-title: Maze learning in planaria.
  publication-title: Worm Runner's Digest
– volume: 14
  start-page: 449
  year: 2004
  ident: ref17
  article-title: Integration of chemosensory pathways in the Drosophila second-order olfactory centers.
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2004.03.006
– volume: 199
  start-page: 2689
  issue: 12
  year: 1996
  ident: ref125
  article-title: Optomotor behaviour in Xenopus laevis tadpoles as a measure of the effect of gravity on visual and vestibular neural integration.
  publication-title: J Exp Biol
  doi: 10.1242/jeb.199.12.2689
– volume: 14
  start-page: 131
  year: 1967
  ident: ref144
  article-title: Automata theory and development: I.
  publication-title: J Theor Biol
  doi: 10.1016/0022-5193(67)90110-5
– volume: 75
  start-page: 18
  year: 2007
  ident: ref31
  article-title: Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants.
  publication-title: Epilepsy Res
  doi: 10.1016/j.eplepsyres.2007.03.015
– volume: 10
  start-page: 451
  year: 2000
  ident: ref136
  article-title: Zebrafish on the move: towards a behavior-genetic analysis of vertebrate vision.
  publication-title: Curr Opin Neurobiol
  doi: 10.1016/S0959-4388(00)00116-1
– volume: 10
  start-page: 901
  year: 2003
  ident: ref177
  article-title: Zebrafish-based small molecule discovery.
  publication-title: Chem Biol
  doi: 10.1016/j.chembiol.2003.10.003
SSID ssj0053866
Score 2.1903794
Snippet A deep understanding of cognitive processes requires functional, quantitative analyses of the steps leading from genetics and the development of nervous system...
SourceID plos
doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e14370
SubjectTerms Algorithms
Animal behavior
Animals
Automation
Brain
Brain - metabolism
Caenorhabditis elegans
Central nervous system
Central Nervous System - metabolism
Cognitive ability
Computer Science/Control Technology
Computer Science/Natural and Synthetic Vision
Computer vision
Design engineering
Developmental biology
Drosophila
Electrodes
Electrophysiology - methods
Engineering
Environmental control
Ethology
Flatworms
Frogs
Genetics
Image Processing, Computer-Assisted - methods
Light
Machine vision
Models, Biological
Multidisciplinary research
Mutation
Nervous system
Neurophysiology
Neuroscience/Animal Cognition
Neuroscience/Behavioral Neuroscience
Neuroscience/Cognitive Neuroscience
Neuroscience/Experimental Psychology
Operant conditioning
Pharmacology
Planarians - metabolism
Quantitative analysis
Regenerative medicine
Software
Standardization
Technology application
Tracking systems
Training
Xenopus laevis - metabolism
Zebrafish
SummonAdditionalLinks – databaseName: DOAJ : directory of open access journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9RADB6hPXFBlFcDBUYICTiEJpnJ67ggqoIESEBRb6N5FqRtsm2SAwf-O_ZkEm1QpXLgsJfY2d3YHj8U-zMhz2tllOV5EiuTQYFiWR4ryVhcsUIbmzOt_PjYx0_F8Qn_cJqf7qz6wp6wER54FNyhkgpKBF0rpzRXWSm5Vq6Asiq1GYQnj14KMW8qpkYfDKe4KMKgHHAeBr283raNxXcPnOFy4p1A5PH6Z6-82m7a7qqU8-_OyZ1QdHSb3Ao5JF2P_32P3LDNHbIXTmlHXwYo6Vd3ye817bDiNfGZv4ZaoMaid6CQrVI59C2krNbQaVUElY2hF4Ns_PAZuEI6DfIDBfFL4AdaR8-nrbqbX3GPg1Y4gUX9Wh06Lorqzrt75OTo3be3x3FYuBDrMuN9nObGKZypLmRaafggOLtMM2MUaK5wCoJ_rcG3soQ7q0qj89pUlWSuNKlKJLtPVg2IeJ9QY4rSVakzdao4ZGmycqkFA-CSGyV5GhE2SV_ogEaOT7oR_hVbCVXJKEyBOhNBZxGJ57u2IxrHNfxvULEzL2Jp-wsgCREsTFxnYRF5imYhxsHU2SOINS8h3eFQv0XkmedAPI0GG3bO5NB14v3n7__A9PXLgulFYHItak-GIQl4JsTpWnAeLDjBK-gFeR-NeJJKJyCvK7IE54bhzsmwrybTmYxfik14jW2HTlSIBshrVN6D8RjMgs080mDGI1IuDshC8ktK8_OHRzNnCIGUsIf_Q1WPyM0stBul5QFZ9ZeDfQxJY6-eeP_wB35abzU
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZge-GCKK8GClgICTiExrHzOqEttCpILdBuUW-RnwVpSZZmc-DAf2cmcUKDKuCwl3iym53xjGdif98Q8qxQRlmRRKEyMRQoliehkpyHOU-1sQnXqoOPHR6lB6fi_Vly5l-4Nf5Y5RATu0Btao3vyHdgXUrjCHGPr1ffQ-wahburvoXGdbIBIThPZmRjd-_o4_EQi8Gb09QD5njGdrx9Xq3qyuIehODYpPjSgtTx9o_RebZa1s1VqeefJygvLUn7t8hNn0vSeW_8TXLNVrfJpvfWhr7wlNIv75Cfc3qCla8J-2toDfrWYpSgkLXSebuuIXW1hi58ywgqK0M_tbLqQGgQEqlnUgThjscEfqB29HDorrv8ES4QcIVILIoN1pa0h3k235q75HR_b_HmIPSNF0KdxWIdssQ4hdjqVLJcwwdJ2iWLjVFgwdQpSAIKDTGWR8JZlRmdFCbPJXeZYSqS_B6ZVaDiLUKNSTOXM2cKpgRkazJ3zMJEEFIYJQULCB-0X2rPSo7NMZZlt9WWQXXSK7NEm5XeZgEJx7tWPSvHP-R30bCjLHJqdxfqi_PSuyikDQqKUV0op7RQcSaFVi6FAp7ZGBKhJCBPcFqUPUB1jAzlXGSQ9gio4wLytJNAXo0KD-6cy7ZpyncfPv-H0MnxROi5F3I1qENLD5aA_4R8XRPJ7YkkRAc9Gd7CSTxopSl_-xHcOUzsq4fpOIxfiofxKlu3TZkjK6Ao0Hj3ezcYFRt3jIOxCEg2cZCJ5qcj1dcvHas5RyqkiD_4-1M9JDdif6CIZdtktr5o7SNIC9fqsff9X9zCZc4
  priority: 102
  providerName: ProQuest
Title A Second-Generation Device for Automated Training and Quantitative Behavior Analyses of Molecularly-Tractable Model Organisms
URI https://www.ncbi.nlm.nih.gov/pubmed/21179424
https://www.proquest.com/docview/1296203479
https://www.proquest.com/docview/821194941
https://pubmed.ncbi.nlm.nih.gov/PMC3003703
https://doaj.org/article/bab924c9bfbc4b27a4cbf68371e22185
http://dx.doi.org/10.1371/journal.pone.0014370
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3Nb9MwFLdGd-GCGF8rjGIhJOCQqY6dODkg1E0rA2kDDYp6i-zY2ZC6pFtaiR3433nPcSKCisahOcTPifK-_F7t93uEvEq10VZE40CbEBIUy6NAK86DhMe5sRHPtSsfOzmNj2fi0zyab5G2Z6tnYL0xtcN-UrPrxf7Pq5v3YPDvXNcGydpJ-8uqtLizILiEJH4b1qYY9fxEdPsKYN1u9xKjliAOx9wX0_3rKb3FymH6d557sFxU9aaw9O_TlX8sV9P75J6PM-mkUYwdsmXLB2THW3JN33i46bcPya8JrTErNsG5u4eSosaiB6EQ0VK1XlUQ1lpD23YSVJWGXq1V6QrUwF3SttgfRhDjBF5QFfSy7by7uAlWWIyFVVrUtd6hTTOp-rJ-RGbTo2-Hx4FvyhDkMhSrgEWm0Fh3HSuW5PBDAHfFQmM0SDcuNAQIaQ7-l49FYbU0eZSaJFG8kIbpseKPyaAEFu8Sakwsi4QVJmVaQCSnkoJZUBKhhNFKsCHhLfez3COW45cuMrcNJyFzaZiZocwyL7MhCbpZywax4xb6AxRsR4t42-4GcCLz5gshhYZENU91oXOhQ6lErosYkntmQwiSoiF5gWqRNcWrndfIJkJCSCQgxxuSl44CMTdKPNRzrtZ1nX38_P0_iL6e9Yhee6KiQukpX0gB34RYXj3KvR4leI68N7yLStxypc4g9kOjEDKFma1ibx6m3TA-FA_qlbZa11mCiIEiReE9acygY2zo0AhDMSSyZyA9zvdHyh8XDvGcI0zSmD-9_bXPyN3QHzhico8MVtdr-xzCxpUekTtyLuGaHDK8Tj-MyPbB0emXs5H7I2bkPMVvvWZ0jw
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VcIALorwaKHSFQMDBbexdvw4IBUpIaVMETVFvZl8uSMEOdSLUA3-J38jMem1qVAGXHnLxjh1nZvbbmezON4Q8SqWWhocDT-oAEhTDQk8KxryERUqbkClpy8cm-9H4kL89Co9WyM-mFgaPVTaYaIFalwr_I9-CdSkKBlj3-GL-zcOuUbi72rTQqN1i15x-h5Ster6zDfZ9HASj19NXY891FfBUHPCF54c6l1g4HAk_UfBBBnLhB1pLeL0ol7DCpQoABBL93MhYqzDVSSJYHmtfDgSD514ilzljKXL1J6M3DfIDdkSRK89jsb_lvGFzXhYGdzw4w5bIZ5Y_2yWgXQt681lZnRfo_nle88wCOLpOrrnIlQ5rV1slK6a4QVYdNlT0qSOwfnaT_BjSA8yztVdfQ9vTbYOYRCFGpsPlooRA2Wg6dQ0qqCg0fb8UhS15AwCmjrcRhC1rCnxBmdNJ08t3dupNsbwL674otnOb0bqotPpa3SKHF2KQ26RXgIrXCNU6ivPEz3XqSw6xoUhy34DbccG1FNzvE9ZoP1OOAx1bccwyu7EXQy5UKzNDm2XOZn3itXfNaw6Qf8i_RMO2ssjgbS-UJ8eZAwQIUiSkviqVuVRcBrHgSuZRAs80AYRdYZ9soFtkdTlsi0PZkMcQZHHIGvvkoZVAFo8Cjwkdi2VVZTvvPv6H0MGHjtATJ5SXoA4lXGkG_CZkB-tIrnckAYtUZ3gNnbjRSpX9nrVwZ-PY5w_Tdhgfikf_ClMuqyxBDkKeovHu1NOgVWxg-Q0D3idxZ4J0NN8dKb58thzqDImXBuzu399qg1wZTyd72d7O_u49cjVwR5n8eJ30FidLcx8C0oV8YFGAkk8XDTu_AMvsoa4
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVEJcEOXVQKErBAIObmLv-nVAKCWNGkpDaVPUm9mXC1KwQ50I9cAf49cxY69NjSrg0kMu3rHjzM5-M5Pd-YaQp7HU0nC_70jtQYJimO9IwZgTsUBp4zMly_Kx_Umwe8zfnvgnK-RnXQuDxyprTCyBWucK_yPvgV8KvD7WPfZSeyziYDh6Pf_mYAcp3Gmt22lUJrJnzr9D-la8Gg9hrp953mhn-mbXsR0GHBV6fOG4vk4lFhEHwo0UfJCNXLie1hJeNUgleLtYAZhA0p8aGWrlxzqKBEtD7cq-YPDca2Q1BK8Ydcjq9s7k4LD2A4AkQWCL9Vjo9qxtbM3zzOD-B2fYIPmCMyx7BjSeoTOf5cVlYe-fpzcvuMPRLXLTxrF0UBneGlkx2W2yZpGioC8snfXLO-THgB5h1q2d6hpaAh0aRCgKETMdLBc5hM1G06ltV0FFpumHpcjKAjiAY2pZHEG45FCBL8hTul939p2dO1Ms9sIqMIrN3Wa0KjEtvhZ3yfGVTMk90slAxeuEah2EaeSmOnYlh0hRRKlrwAi54FoK7nYJq7WfKMuIjo05Zkm5zRdCZlQpM8E5S-ycdYnT3DWvGEH-Ib-NE9vIIp93eSE_O00sPEDIIiERVrFMpeLSCwVXMg0ieKbxIAjzu2QTzSKpimMbVEoGPISQi0MO2SVPSgnk9MhwdZyKZVEk4_cf_0Po6LAl9NwKpTmoQwlbqAG_CbnCWpIbLUlAJtUaXkcjrrVSJL_XMNxZG_blw7QZxofiQcDM5MsiiZCRkMc4eferZdAo1ivZDj3eJWFrgbQ03x7JvnwuGdUZ0jD12YO_v9UmuQ6Qk7wbT_YekhuePdfkhhukszhbmkcQnS7kYwsDlHy6auT5BUbOp0k
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+second-generation+device+for+automated+training+and+quantitative+behavior+analyses+of+molecularly-tractable+model+organisms&rft.jtitle=PloS+one&rft.au=Blackiston%2C+Douglas&rft.au=Shomrat%2C+Tal&rft.au=Nicolas%2C+Cindy+L&rft.au=Granata%2C+Christopher&rft.date=2010-12-17&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=5&rft.issue=12&rft.spage=e14370&rft_id=info:doi/10.1371%2Fjournal.pone.0014370&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon