Dendritic cells in chronic mycobacterial granulomas restrict local anti-bacterial T cell response in a murine model

• Published in: PloS one Vol. 5; no. 7; p. e11453
• Main Authors: Schreiber, Heidi A, Hulseberg, Paul D, Lee, JangEun, Prechl, Jozsef, Barta, Peter, Szlavik, Nora, Harding, Jeffrey S, Fabry, Zsuzsanna, Sandor, Matyas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.07.2010; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Antibacterial agents; Antigen 85B; Antigens; Antigens, Bacterial - immunology; Antigens, CD - metabolism; Antiinfectives and antibacterials; B cells; B7-1 Antigen - metabolism; B7-2 Antigen - metabolism; B7-H1 Antigen; Bacillus Calmette-Guerin vaccine; Bacteria; BCG; CD11c antigen; CD11c Antigen - metabolism; CD4 antigen; CD4-Positive T-Lymphocytes - metabolism; CD40 antigen; CD40 Antigens - metabolism; CD80 antigen; CD86 antigen; Cell activation; Cell survival; Cells, Cultured; Chronic infection; Cost analysis; Costimulator; Cytokines; Data processing; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Flow Cytometry; Gene expression; Granuloma; Granuloma - immunology; Granuloma - metabolism; Health aspects; Immune response; Immune system; Immunoglobulins; Immunology; Immunology/Cellular Microbiology and Pathogenesis; Immunology/Immune Response; Immunology/Immunity to Infections; Infection; Infections; Infectious Diseases/Bacterial Infections; Inflammation; Intercellular Signaling Peptides and Proteins - metabolism; Interferon-gamma - metabolism; Laboratories; Latent infection; Lesions; Lymphocytes; Lymphocytes T; Medicine; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mycobacterium; Mycobacterium avium; Mycobacterium bovis; Mycobacterium bovis - immunology; Mycobacterium Infections - immunology; Mycobacterium tuberculosis; Pathology; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Ligand 2 Protein; Public health; Rodents; Signal transduction; Signaling; Survival; T cells; T-Lymphocytes - metabolism; T-Lymphocytes - microbiology; Training; Tuberculosis; γ-Interferon; San Francisco California; California; Hungary; United States > US; Wisconsin

Mycobacterium-induced granulomas are the interface between bacteria and host immune response. During acute infection dendritic cells (DCs) are critical for mycobacterial dissemination and activation of protective T cells. However, their role during chronic infection in the granuloma is poorly unders...