Detection of Extensive Cross-Neutralization between Pandemic and Seasonal A/H1N1 Influenza Viruses Using a Pseudotype Neutralization Assay

• Published in: PloS one Vol. 5; no. 6; p. e11036
• Main Authors: Labrosse, Béatrice, Tourdjman, Mathieu, Porcher, Raphaël, LeGoff, Jérôme, de Lamballerie, Xavier, Simon, François, Molina, Jean-Michel, Clavel, François
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.06.2010; Public Library of Science (PLoS)
• Subjects: Age; Assaying; Health aspects; HIV; HIV-1 - immunology; Human immunodeficiency virus; Humans; Immunity; Immunoglobulins; Infection; Infections; Influenza; Influenza A Virus, H1N1 Subtype - immunology; Influenza vaccines; Middle Aged; Neutralization; Neutralization Tests; Neutralizing; Pandemics; Public health; Sensitivity and Specificity; Swine flu; Vaccination; Vaccines; Virology/Emerging Viral Diseases; Virology/Host Antiviral Responses; Virology/Host Invasion and Cell Entry; Viruses; United States > US

Cross-immunity between seasonal and pandemic A/H1N1 influenza viruses remains uncertain. In particular, the extent that previous infection or vaccination by seasonal A/H1N1 viruses can elicit protective immunity against pandemic A/H1N1 is unclear. Neutralizing titers against seasonal A/H1N1 (A/Brisb...