Diffusion Tensor Imaging and Decision Making in Cocaine Dependence

• Published in: PloS one Vol. 5; no. 7; p. e11591
• Main Authors: Lane, Scott D., Steinberg, Joel L., Ma, Liangsuo, Hasan, Khader M., Kramer, Larry A., Zuniga, Edward A., Narayana, Ponnada A., Moeller, Frederick Gerard
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.07.2010; Public Library of Science (PLoS)
• Subjects: Abnormalities; Adult; Alcohol; Alcohol use; Anisotropy; Attention deficit hyperactivity disorder; Behavioral sciences; Brain; Cocaine; Cocaine-Related Disorders - physiopathology; Corpus callosum; Decision making; Decision Making - physiology; Diffusion; Diffusion Tensor Imaging - methods; Drug abuse; Eigenvalues; Female; Gambling; Humans; Impairment; Integrity; Magnetic resonance imaging; Male; Mental Health/Psychology; Mental Health/Psychopharmacology; Mental Health/Substance Abuse; Narcotics; Neuroimaging; Neuroscience/Neurobiology of Disease and Regeneration; Neuroscience/Psychology; Neurosciences; Psychiatry; Studies; Substantia alba; Tobacco; Trauma centers; United States > US; Texas

Chronic stimulant abuse is associated with both impairment in decision making and structural abnormalities in brain gray and white matter. Recent data suggest these structural abnormalities may be related to functional impairment in important behavioral processes. In 15 cocaine-dependent and 18 cont...