Comprehensive Genotyping in Two Homogeneous Graves' Disease Samples Reveals Major and Novel HLA Association Alleles

• Published in: PloS one Vol. 6; no. 1; p. e16635
• Main Authors: Chen, Pei-Lung, Fann, Cathy Shen-Jang, Chu, Chen-Chung, Chang, Chien-Ching, Chang, Su-Wei, Hsieh, Hsin-Yi, Lin, Marie, Yang, Wei-Shiung, Chang, Tien-Chun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.01.2011; Public Library of Science (PLoS)
• Subjects: Alleles; Analysis; Arthritis; Asian Continental Ancestry Group - genetics; Biology; Biometrics; Case-Control Studies; Disease; DNA fingerprints; Drb1 protein; Eye; Eye diseases; Family; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genomes; Genotype; Genotyping; Graves Disease - ethnology; Graves Disease - genetics; Graves' disease; Haplotypes; Heterogeneity; Histocompatibility antigen HLA; HLA antigens; HLA Antigens - genetics; HLA-DP Antigens; HLA-DR Antigens; Hospitals; Humans; Hyperthyroidism; Hypotheses; Hypothyroidism; Internal medicine; Laboratories; Leukocytes; Lupus; Medical research; Medicine; Population; Population genetics; Populations; Prevalence studies (Epidemiology); Studies; Taiwan; Thyroid; Thyroid gland; Thyroid hormones; Values; White people; Working groups; Taiwan

Graves' disease (GD) is the leading cause of hyperthyroidism and thyroid eye disease inherited as a complex trait. Although geoepidemiology studies showed relatively higher prevalence of GD in Asians than in Caucasians, previous genetic studies were contradictory concerning whether and/or which...