Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats

• Published in: PloS one Vol. 5; no. 8; p. e12490
• Main Authors: Abdel Baki, Samah G, Schwab, Ben, Haber, Margalit, Fenton, André A, Bergold, Peter J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.08.2010; Public Library of Science (PLoS)
• Subjects: Acetylcysteine; Acetylcysteine - pharmacology; Animals; Antibiotics; Avoidance; Avoidance Learning - drug effects; Brain; Brain injuries; Brain Injuries - metabolism; Brain Injuries - pathology; Brain Injuries - physiopathology; Clinical trials; Cognition; Cognition & reasoning; Cognition - drug effects; Combination drug therapy; Conditioning, Psychological; Cortex; Cyclosporins; Drug approval; Drug Synergism; Drug therapy; Drugs; Head injuries; Histology; Injury prevention; Interleukin 1; Interleukin-1beta - biosynthesis; Interleukins; Learning; Medical research; Memory; Memory - drug effects; Minocycline; Minocycline - pharmacology; Myelin; Myelin Sheath - metabolism; Neurological Disorders/Neurorehabilitation and Trauma; Neuroscience/Neurobiology of Disease and Regeneration; Neuroscience/Neuronal and Glial Cell Biology; Perception - drug effects; Progesterone; Rats; Rats, Sprague-Dawley; Regulatory agencies; Rodents; Sex hormones; Simvastatin; Spacecraft; Substantia grisea; Task Performance and Analysis; Time Factors; Traumatic brain injury; New York; United States > US

There are no drugs presently available to treat traumatic brain injury (TBI). A variety of single drugs have failed clinical trials suggesting a role for drug combinations. Drug combinations acting synergistically often provide the greatest combination of potency and safety. The drugs examined (mino...