Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

• Published in: EMBO reports Vol. 9; no. 7; pp. 670 - 675
• Main Authors: Rigali, Sébastien, Titgemeyer, Fritz, Barends, Sharief, Mulder, Suzanne, Thomae, Andreas, Hopwood, David, van Wezel, Gilles
• Format: Journal Article Web Resource
• Language: English
• Published: Chichester, UK Nature Publishing Group 01.07.2008; John Wiley & Sons, Ltd; Nature Publishing Group UK; Blackwell Publishing Ltd
• Subjects: Acetylglucosamine - metabolism; Anti-Bacterial Agents - biosynthesis; antibiotic production; Antibiotics; Bacterial Proteins - metabolism; Biochemistry; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; biophysics; Biosynthesis; Culture Media; DasR; development; EMBO06; EMBO11; Famine; Life sciences; Metabolites; Microbiologie; Microbiology; Molecular biology; N-acetylglucosamine; nutrient sensing; Nutrient status; Nutrients; Pathogens; regulation; Sciences du vivant; Scientific Report; secondary metabolism; secondary metabolite; Secondary metabolites; Signal Transduction; signalling; signalling cascade; Soil microorganisms; Streptomyces; Streptomyces coelicolor - metabolism; Stress; development; regulation; secondary metabolism; signalling; nutrient sensing

Members of the soil‐dwelling prokaryotic genus Streptomyces produce many secondary metabolites, including antibiotics and anti‐tumour agents. Their formation is coupled with the onset of development, which is triggered by the nutrient status of the habitat. We propose the first complete signalling c...