Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

• Published in: Nature Vol. 455; no. 7209; pp. 114 - 118
• Main Authors: Heng, Julian Ik-Tsen, Nguyen, Laurent, Castro, Diogo S., Zimmer, Céline, Wildner, Hendrik, Armant, Olivier, Skowronska-Krawczyk, Dorota, Bedogni, Francesco, Matter, Jean-Marc, Hevner, Robert, Guillemot, François
• Format: Journal Article Web Resource
• Language: English
• Published: London Nature Publishing Group UK 04.09.2008; Nature Publishing; Nature Publishing Group
• Subjects: 3' Untranslated Regions - genetics; Animals; Basic Helix-Loop-Helix Transcription Factors - deficiency; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Basic Helix-Loop-Helix Transcription Factors/deficiency/genetics/metabolism; Binding proteins; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; Biological and medical sciences; Cell migration; Cell Movement; Cell Shape; Cerebral cortex; Cerebral Cortex - cytology; Cerebral Cortex - embryology; Cerebral Cortex - metabolism; Cerebral Cortex/cytology/embryology/metabolism; Enhancer Elements, Genetic - genetics; Fundamental and applied biological sciences. Psychology; Gene Deletion; Gene Expression Regulation, Developmental; General aspects. Models. Methods; Humanities and Social Sciences; letter; Life sciences; Mice; multidisciplinary; Nerve Tissue Proteins - deficiency; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nerve Tissue Proteins/deficiency/genetics/metabolism; Neurons; Neurons - cytology; Neurons - metabolism; Neurons/cytology/metabolism; Physiological aspects; Proteins; rho GTP-Binding Proteins - deficiency; rho GTP-Binding Proteins - genetics; rho GTP-Binding Proteins - metabolism; rho GTP-Binding Proteins/deficiency/genetics/metabolism; RNA Interference; Science; Science (multidisciplinary); Sciences du vivant; Transgenic animals; Vertebrates: nervous system and sense organs; Cerebral cortex; Embryo; Motility; Rodentia; Central nervous system; Neurogenesis; Encephalon; Cell motility; Vertebrata; Mammalia; Neuron; Mouse; Animal; Behavior; Mutation; G protein

Neuronal migration: neurogenin 2 acts via Rnd2 Proneural transcription factors, such as neurogenin 2, are thought to control the expression of many genes during brain development to promote both the differentiation of neurons and their migration to their final locations in the cerebral cortex. A new...