Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs

• Published in: Angewandte Chemie International Edition Vol. 55; no. 11; pp. 3772 - 3775
• Main Authors: Bremer, Paul T., Kimishima, Atsushi, Schlosburg, Joel E., Zhou, Bin, Collins, Karen C., Janda, Kim D.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 07.03.2016; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Ablation; Abuse; Analgesics, Opioid - toxicity; Analytical methods; Animals; Antibodies; antibody; Antidotes - therapeutic use; biosensors; conjugate vaccines; Cross-reactivity; Designer Drugs - chemical synthesis; Drug abuse; Drug addiction; Drug dosages; Drugs; Fentanyl; Fentanyl - pharmacokinetics; Fentanyl - toxicity; fentanyls; immunology; Immunotherapy; Mice; Morphine; Narcotics; Opioids; Overdose; Pain management; Surface plasmon resonance; Tissue Distribution; Toxicology; Vaccines; Vaccines - administration & dosage; biosensors; antibody; fentanyls; immunology; conjugate vaccines

Fentanyl is an addictive prescription opioid that is over 80 times more potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous “designer drug” analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large numb...