Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance

• Published in: The Lancet (British edition) Vol. 381; no. 9885; pp. 2273 - 2279
• Main Authors: Hu, Yunwen, Lu, Shuihua, Song, Zhigang, Wang, Wei, Hao, Pei, Li, Jianhua, Zhang, Xiaonan, Yen, Hui-Ling, Shi, Bisheng, Li, Tao, Guan, Wencai, Xu, Lei, Liu, Yi, Wang, Sen, Zhang, Xiaoling, Tian, Di, Zhu, Zhaoqin, He, Jing, Huang, Kai, Chen, Huijie, Zheng, Lulu, Li, Xuan, Ping, Jie, Kang, Bin, Xi, Xiuhong, Zha, Lijun, Li, Yixue, Zhang, Zhiyong, Peiris, Malik, Yuan, Zhenghong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 29.06.2013; Elsevier; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - therapeutic use; Base Sequence; Binding sites; Biological and medical sciences; blood serum; China; China - epidemiology; Chronic obstructive pulmonary disease; Cyclopentanes - therapeutic use; Drug Resistance, Viral; Epidemiology; Family planning; Female; General aspects; Genes; Genomes; Guanidines - therapeutic use; human diseases; Humans; Infectious diseases; Influenza; Influenza A virus - drug effects; Influenza A virus - genetics; Influenza A virus - physiology; Influenza, Human - drug therapy; Influenza, Human - epidemiology; Influenza, Human - virology; Internal Medicine; Male; Medical sciences; Microbiology; Middle Aged; Molecular Sequence Data; mutants; Mutation; oseltamivir; Oseltamivir - therapeutic use; Oxygenation; pandemic; Pandemics; Patients; peramivir; Pharmacology. Drug treatments; planning; Pneumonia; Public health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Respiratory diseases; Respiratory distress syndrome; RNA; RNA, Viral - genetics; sialidase; therapeutics; throat; urine; Ventilation; viral load; viral shedding; Virus Shedding; Viruses; China; China, People's Rep., Shanghai; China, People's Rep; Human; Disease; Orthomyxoviridae; Epidemiology; Virus; Medicine; Resistance; Influenzavirus A; Association; Influenza A virus; Emergence; Antiviral; Complication; Viral load

On March 30, a novel influenza A subtype H7N9 virus (A/H7N9) was detected in patients with severe respiratory disease in eastern China. Virological factors associated with a poor clinical outcome for this virus remain unclear. We quantified the viral load and analysed antiviral resistance mutations...