Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds - Li, Zhaoyang; Wang, Cen; Wang, Ziying; Zhu, Chenggang; Li, Jie; Sha, Tian; Ma, Lixiang; Gao, Chao; Yang, Yi; Sun, Yimin; Wang, Jian; Sun, Xiaoli; et al. (Nature (London), 2019)
Keywords: 13/106; 13/89; 13/95; 132/122; 14/19; 631/154/1435/2163; 631/378/1689/1558; 631/61/32; 631/80/39; 631/92/507; 64/24; 64/60; 82/1; 82/58; 82/80; 96/109; 96/33; Alleles; Allelomorphism; Analysis; Animal models; Animals; Ataxin; Ataxin-3 - genetics; Autophagosomes - metabolism; Autophagy; Chemical compounds; Crosslinking; Disease Models, Animal; Drosophila melanogaster - genetics; Drosophila Proteins - antagonists & inhibitors; Drosophila Proteins - chemistry; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Drug Evaluation, Preclinical - methods; Female; Genetic aspects; Humanities and Social Sciences; Humans; Huntingtin; Huntingtin Protein - antagonists & inhibitors; Huntingtin Protein - chemistry; Huntingtin Protein - genetics; Huntingtin Protein - metabolism; Huntington's chorea; Huntington's disease; Huntingtons disease; Immunoassay; Influence; Kinases; Male; Mice; Microtubule-associated protein 1; Microtubule-Associated Proteins - genetics; multidisciplinary; Mutant Proteins - antagonists & inhibitors; Mutant Proteins - chemistry; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutants; Mutation - drug effects; Mutation - genetics; Neurodegeneration; Neurodegenerative diseases; Neurons - cytology; Peptides - genetics; Phagosomes; Phenotype; Phenotypes; Polyglutamine diseases; Proteins; Reproducibility of Results; Science; Science (multidisciplinary); Stem cells; Tethering; Trinucleotide repeat diseases; China