TRIM24 links a non-canonical histone signature to breast cancer

• Published in: Nature (London) Vol. 468; no. 7326; pp. 927 - 932
• Main Authors: Tsai, Wen-Wei, Wang, Zhanxin, Yiu, Teresa T., Akdemir, Kadir C., Xia, Weiya, Winter, Stefan, Tsai, Cheng-Yu, Shi, Xiaobing, Schwarzer, Dirk, Plunkett, William, Aronow, Bruce, Gozani, Or, Fischle, Wolfgang, Hung, Mien-Chie, Patel, Dinshaw J., Barton, Michelle Craig
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.12.2010; Nature Publishing Group
• Subjects: 631/45; 692/699/67/1347; Acetylation; Biological and medical sciences; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carrier Proteins - chemistry; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line, Tumor; Chromatin; Chromatin - metabolism; Chromatin Assembly and Disassembly; Crystallography, X-Ray; Development and progression; Estrogen Receptor alpha - metabolism; Estrogens - metabolism; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genetic aspects; Gynecology. Andrology. Obstetrics; Health aspects; HEK293 Cells; Histones; Histones - chemistry; Histones - metabolism; Humanities and Social Sciences; Humans; Mammary gland diseases; Medical sciences; Methylation; multidisciplinary; Physiological aspects; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary; Proteins; Science; Science (multidisciplinary); Structure; Substrate Specificity; Survival Rate; Tumors; United States; Human; Cell proliferation; Breast disease; Breast cancer; Malignant tumor; Carcinogenesis; Mammary gland diseases; Cancerology; Gene; Genetics; Bromodomain; Histone; Cancer; Homeodomain

Recognition of modified histone species by distinct structural domains within ‘reader’ proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific b...